血β-HCG、血钙、血细胞比容、平均动脉压联合预测子间疒前期的价值  

Study on prediction of pre-eclampsia by measuring β-HCG, blood calcium, hematocrit and mean arterial pressure

作　　者：吴曼祯 陈文[1] 陈秀华[1] 黄远征[1] 卢冬青[1] 

机构地区：[1]广东省汕头市第二人民医院妇产科,515011

出　　处：《中国医师进修杂志》2006年第3期16-18,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨血β-HCG、血钙、血细胞比容、平均动脉压联合预测子痫前期的临床可行性。以及钙剂预防子痢前期发生的临床价值。方法对356名孕妇在妊娠16～20周时测定血β-HCG、血钙、血细胞比容，同时测量平均动脉压进行前瞻性研究。将血β-HCG≥50632IU／L，血钙≤2．18mmol／L，血细胞比容≥0．35，平均动脉压≥85mmHg（1mmHg=0．133kPa）者判定为阳性，并随机分为治疗组与对照组。治疗组给予钙剂与维生素D预防性治疗，随访并观察子痢前期发生与否。结果发现系列试验阳性者共71例，其阳性预测率为81．82％，阴性预测率为97．30％，敏感度为84．38％，特异度为96．77％。治疗组子痢前期发生率明显下降，与对照组差异有统计学意义。结论孕中期联合检测血β-HCG、血钙、血细胞比容、平均动脉压对预测子痫前期有较高的敏感性和特异性，方法简单易行，值得临床推广应用。预防性治疗可明显降低子痫前期的发生。Objective To investigate the clinical viability of pre-eclampsia by measuring the level of β-HCG in blood, blood calcium, hematocrit （HCT）,and the mean arterial blood pressure（mABP）. The preventive value of calcium supplement was also evaluated. Methods 356 volunteers＇ （16th-20th gestational weeks）were measured β- HCG in blood, blood calcium, HCT, meanwhile mABP from the same patients. If blood β - HCG≥50 632 IU/L. blood calcium≤2.18 mmol/L, HCT≥0.35 and mABP≥85 mmHg（ 1mmHg= 0.133 kPa）, a positive conclusion was made, Women with positive results were randomly divided into test group and control group. Results 71 cases turned out to be positive in this serial test. The positive predictive value was 81. 82%, negative predictive value was 97.30%, the .sensitivity and specificity were 84.38% and 96.77% respectively. In the study group, the incidence of pre- eclampsia was significantly decreased as compared with the control group （P 〈 0.01 ）. Couclusions This serial test may be recommended as a better clinical forecast test of pre-eclampsia. And preventive treatment can effectively prevent the incidence of pre-eclampsia.

关 键 词：血β—HCG 血钙 血细胞比容 平均动脉压 子痢前期 预测 预防 

分 类 号：R714.246[医药卫生—妇产科学]