补肾益气活血汤对小鼠血清雌、孕激素浓度及其受体表达的影响  

Clinical Significance of High Frequency Ultrasound in Detection of Thyroid Nodule Calcification

作　　者：吴云霞[1] 黄光英[2] 

机构地区：[1]华中科技大学同济医学院药学院生药系,武汉430030 [2]华中科技大学同济医学院附属同济医院中西结合研究所

出　　处：《现代生物医学进展》2006年第2期19-21,共3页Progress in Modern Biomedicine

基　　金：国家高等学校博士学科点专项科研基金资助(NO:20020487058)

摘　　要：目的:探讨中药补肾益气活血汤促进着床的机理。方法:在以吲哚美辛建立小鼠着床障碍模型的基础上,将动物分为正常组,吲哚美辛组,中药组和黄体酮组,用放射免疫、免疫组织化学及Western-blot方法检测各组小鼠妊娠d5(围着床期)血清E2,P4浓度及子宫内膜ER,PR表达。结果:补肾益气活血中药对E2、P4水平无明显影响,对PR表达也无明显影响,但有轻度促进ERα表达作用,此外,实验发现治疗对照组注射黄体酮虽然使P4水平升高,但ERα、PR表达却都有一定下降。结论:提示中药补肾益气活血汤可能主要通过雌激素样活性加强E2与其受体作用而有利于发动蜕膜化从而促进着床,黄体酮辅助生殖治疗失败可能与孕酮一定程度上抑制ERα和PR表达有关。Objective： To investigate the clinical significance of thyroid calcification in the differential diagnosis of thyroid carcinoma. Methods： The clinical data of 77 patients（male：20,female：57） with thyroid nodules, who were confirmed by preoperative ultrasonic examination and postoperative pathological results, were retrospectively analysed. Results： Among the patients, there were 20 with benign nodules, 56 with malignant tumor, and 1 with precancerous lesion. In this study, calcification rates in benign and malignant diseases were 10% and 14.28% respectively, with significant difference. Conclusion： According to the size of thyroid nodule calcification, whether malignant disease or not can be diagnosed, so if micro- calcification in thyroid nodules is detected by preoperative ultrasound, malignant tumor of thyroid should be highly doubted and paid more attention to, especially for the young or patients with single nodule.

关 键 词：补肾益气活血汤 雌激素 孕激素 

分 类 号：Q959.837[生物学—动物学] S852.21[农业科学—基础兽医学]