Effects of exercise on neurogenesis in the dentate gyrus and ability of learning and memory after hippocampus lesion in adult rats  

作　　者：Lin CHEN Shan GONG Li-Dong SHAN Wei-Ping XU Yue-Jin ZHANG Shi-Yu GUO Tadashi Hisamitsu Qi-Zhang YIN Xing-Hong JIANG 

机构地区：[1]Department of Neurobiology, School of Medicine, Soochow University, Suzhou 215123, China [2]Department of Physiology, School of Medicine, Showa University, Tokyo 142-8555, Japan [3]Now in Department of Physiology, School of Preclinic Medicine, Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China

出　　处：《Neuroscience Bulletin》2006年第1期1-6,共6页神经科学通报（英文版）

摘　　要：Objective To explore the effects of exercise on dentate gyrus （DG） neurogenesis and the ability of learning and memory in hippocampus-lesioned adult rats. Methods Hippocampus lesion was produced by intrabippocampal microinjection of kainic acid （KA）. Bromodeoxyuridine （BrdU） was used to label dividing cells. Y maze test was used to evaluate the ability of learning and memory. Exercise was conducted in the form of forced running in a motor-driven running wheel. The speed of wheel revolution was regulated at 3 kinds of intensity： lightly running, moderately running, or heavily running. Results Hippocampus lesion could increase the number of BrdU-labeled DG cells, moderately running after lesion could further enhance the number of BrdU-labeled cells and decrease the error number （EN） in Y maze test, while neither lightly running, nor heavily running had such effects. There was a negative correlation between the number of DG BrdU-labeled cells and the EN in the Y maze test after running. Conclusion Moderate exercise could enhance the DG neurogenesis and ameliorate the ability of learning and memory in hippocampus-lesioned rats.Objective To explore the effects of exercise on dentate gyrus (DG) neurogenesis and the ability of learning and memory in hippocampus-lesioned adult rats. Methods Hippocampus lesion was produced by intrahippocampal microinjection of kainic acid (KA). Bromodeoxyuridine (BrdU) was used to label dividing cells. Y maze test was used to evaluate the ability of learning and memory. Exercise was conducted in the form of forced running in a motor-driven running wheel. The speed of wheel revolution was regulated at 3 kinds of intensity: lightly running, moderately running, or heavily running. Results Hippocampus lesion could increase the number of BrdU-labeled DG cells, moderately running after lesion could further enhance the number of BrdU-labeled cells and decrease the error number (EN) in Y maze test, while neither lightly running, nor heavily running had such effects. There was a negative correlation between the number of DG BrdU-labeled cells and the EN in the Y maze test after running. Conclusion Moderate exercise could enhance the DG neurogenesis and ameliorate the ability of learning and memory in hippocampus-lesioned rats.

关 键 词：NEUROGENESIS dentate gyms kainic acid learning and memory EXERCISE running BROMODEOXYURIDINE 

分 类 号：Q189[生物学—神经生物学] Q253[生物学—普通生物学]