血清PINP和ICTP及PCⅢ检测对肝病诊断价值的研究  

Experimental study on PINP, ICTP and PCⅢ in the serum of hepatic space-occupying lesions

作　　者：杜明华[1] 钟英[1] 张卫国[2] 吴巍[3] 闵捷[4] 

机构地区：[1]东南大学附属中大医院核医学科,江苏南京210009 [2]东南大学附属中大医院临床检验中心,江苏南京210009 [3]东南大学公共卫生学院毒理教研室,江苏南京210009 [4]东南大学公共卫生学院卫生统计教研室,江苏南京210009

出　　处：《中华肿瘤防治杂志》2006年第4期245-247,278,共4页Chinese Journal of Cancer Prevention and Treatment

基　　金：国家十五科技攻关计划资助项目(2004BA706B03-01)

摘　　要：目的:1)了解Ⅰ型前胶原氨端肽原(PINP)、Ⅰ型胶原羧端交联肽原(ICTP)和Ⅲ型前胶原(PCⅢ)三项肝纤维化指标在原发性肝癌、转移性肝癌和肝硬化血清中的变化。2)了解PINP、ICTP和PCⅢ三项肝纤维化指标、肝肿瘤指标和肝功指标之间的关系。方法:实验分四组:正常对照组30例,73例患者中原发性肝癌组28例,转移性肝癌组23例,肝硬化组22例。测定PINP、ICTP、PCⅢ、甲胎蛋白(AFP)、癌胚抗原(CEA)、糖类抗原(CA-199)、谷丙转氨酶(AST)、谷草转氨酶(ALT)和谷氨酰氨转酞酶(γ-GT)九项指标。结果:1)73例患者PINP、ICTP和PCⅢ水平均明显高于正常对照组,P<0·01;但PINP、ICTP和PCⅢ在原发性肝癌组和转移性肝癌组比较差异无统计学意义,P>0·05。2)AFP和肝功能指标在原发性肝癌组明显升高,和转移性肝癌组比较差异有统计学意义,P<0·01;CEA和CA-199在转移性肝癌组明显升高,和原发性肝癌组比较差异有统计学意义,P<0·05。3)PINP、ICTP和PCⅢ与肝肿瘤指标和肝功能指标之间的相关分析无相关关系,P>0·05。结论:1)PINP、ICTP和PCⅢ对了解肝内占位性病变的纤维化程度有一定的帮助;2)原发性肝癌和转移性肝癌的九项指标有一定差异;3)PINP、ICTP和PCⅢ与肝肿瘤指标和肝功能指标之间无相关关系。OBJESTIVE： To study the change of N-terminal propetide of typel procollagen （PINP）, C-terminal telopetide of typel procollagen （ICTP）, type Ⅲ procollagen （PCⅢ） in the serum of primary carcinoma of the liver and hepatic metastases and to study the relationship among the hepatic serum fibrosis indexes, hepatic carcinoma indexes and hepatic function indexes. METHODS： The studied groups included the control group （30 cases）, the primary groups carcinoma group （28 cases）, the hepatic metastases group （23 cases） and hepatic cirrhosis group （23 cases）. Nine serum indexes （PINP, ICTP, PCⅢ, AFP, CEA, CA-199, AST, ALT, and γ-GT） were detected. RESULTS：1） The serum PINP, ICTP and PCⅢ fibrosis indexes of the primary hepatic carcinoma group and the hepatic metastases group were significantly higher than those of the control group, P〈0. 01;and no significient difference was found in the levels of PINP, ICTP, and PCⅢ between the primary carcinoma group and the hepatic metastases group, P〉0. 05. 2） The level of AFP and the hepatic function indexes were signficantly higher in the primary hepatic carcinoma group than those in the hepatic metastases group, P〈0. 01. While both CEA and CA-199 in the hepatic metastases group were remarkably higher than those in the primary hepatic carcinoma group, P〈0. 05. 3）Tbere was no correlation betwen PINP, ICTP, PCⅢ fibrosis indexes and carcinoma index or function indexes. CONCLUSIONS： 1） Three fibrosis indexes including PINP, ICTP, PCⅢ could indicate the development of hepatofibrosis in liver carcinoma; 2） There are some differences among the 9 indexes between the primary hepatic carcinoma group and the hepatic metastases group; 3） There is no correlation between the serum PINP, ICTP, PCⅢ fibrosis indexes and carcinoma indexes or function indexes.

关 键 词：肝肿瘤 肝硬化 前胶原/血液 放射免疫测定 

分 类 号：R817.4[医药卫生—影像医学与核医学]