孟鲁司特钠对慢性阻塞性肺疾病急性加重期黏附因子的影响  

Effect of montelukast sodium on adhesion molecule in the acute exacerbation period of chronic obstructive pulmonary disease

作　　者：吴纪珍[1] 马利军[1] 李素云[2] 李建生[2] 李成海[1] 

机构地区：[1]河南省人民医院呼吸内科,郑州450003 [2]河南中医学院第一附属医院呼吸内科,郑州450003

出　　处：《中国临床药学杂志》2006年第2期110-112,共3页Chinese Journal of Clinical Pharmacy

基　　金：河南省科技厅攻关课题基金资助(编号:001170711)

摘　　要：目的探讨老年慢性阻塞性肺疾病(COPD)急性加重期血清黏附分子的变化及孟鲁司特钠对其影响。方法56例COPD急性加重期患者分为治疗组和对照组。治疗组在综合治疗的基础上,口服孟鲁司特钠10 mg,qn,连用4 wk,对照组除不用孟鲁司特外,余治疗同治疗组。治疗前后检测COPD患者血清中黏附分子的水平并与20例健康老年人作对照。结果COPD急性加重期患者血清可溶性细胞间黏附分子-1(sICAM-1)、E-选择素(sE-SLT)均明显高于老年健康组(P<0.01);治疗后治疗组和对照组sICAM-1s、E-SLT水平均明显降低(P<0.01),但治疗组上述指标的降低较对照组显著(P<0.01)。COPD程度分级治疗组改善优于对照组。结论老年COPD急性加重期黏附分子明显高于健康老年人,孟鲁司特钠能降低黏附分子水平,治疗老年COPD急性加重期疗效可靠。AIM To study the effect of montdukast sodium on adhesion molecule in the acute exacerbation period of chronic obstructive pulmonary disease（COPD） in senile patients. METHODS Fifty-six patients with COPD in acute exacerbation period were divided into treatment group and control group. The treatment group took montelukast sodium 10 nag orally before sleeping for 4 wk totally, in addition to the routine therapy. Control group received routine therapy. The level of adhesion molecule in COPD patients and 20 health subjects was compared before and after treatment. RESULTS The level of slCAM-1 and sE-SLT was obviously higher in COPD patients than that in health subjects（ P 〈 0.01）. And the level of them was decreased greatly after treatment in both groups. COPD degree was superior in treatment group to control group. CONCLUSION The change of adhesion molecule was involved in the acute exacerbation period of COPD. That montelukast sodium decreases adhesion molecule level is properly one of the mechanisms of treating senile COPD.

关 键 词：慢性阻塞性肺疾病 血清黏附分子-1 E-选择素 孟鲁司特钠 

分 类 号：R563.9[医药卫生—呼吸系统]