脑外伤后迟发性脑梗塞患者急性期纤溶状态研究  

Study on coagulation and fibrinolysis in patients with late cerebral infarction after acute brain injury

作　　者：罗晓阳[1] 陈学华[1] 潘志汉[1] 陈国永[1] 胡振华[1] 

机构地区：[1]东莞市太平人民医院神经外科,广东东莞523900

出　　处：《中华神经外科疾病研究杂志》2006年第2期132-134,共3页Chinese Journal of Neurosurgical Disease Research

摘　　要：目的初步探讨脑外伤后迟发性脑梗塞患者急性期血浆及脑脊液凝血纤溶状态变化,为临床脑外伤后迟发性脑梗塞提供诊治依据。方法脑外伤后迟发性脑梗塞患者72例,采集血浆,同时采集脑脊液,测定脑脊液及血浆部分凝血纤溶指标,并与171例脑外伤后无脑梗塞患者对照进行比较。结果脑外伤后迟发性脑梗塞组(实验组)脑脊液及血浆组织型纤溶酶原激活物(t-PA)、D-二聚体(D-D)含量明显高于非脑梗塞组(对照组)(P<0.01)而纤溶酶原(PLG)活性明显下降(P<0.01)。结论脑外伤后迟发性脑梗塞患者急性期存在明显的高凝状态和继发性纤溶活性增高。Objective To investigate the concentration of D-dimer（D-D）, tissue -type plasminogen activator （t-PA） and plasminogen （PIG） activity in plasma and cerebrospinal fluid in patients with late cerebral infarction after acute brain injury and to probe their clinical significance. Methods The concentration of D-dimer and t-PA in plasma and cerebrespinal fluid in patients with late cerebral infarction after acute brain injury were examined by enzyme hnked-immunsorbent assay （ELISA） and the measurement for PIG biological activity was performed by the chromophore method. All these results were compared with those of patients in control group. Results The concentrations of D-dimer and t-PA in patients with late cerebral infarction after acute brain injury were much higher than those in patients without cerebral infarction （P〈0.01）, while the PIG activity was significantly lower in the former （P〈0.01）. Conclusion Hypercoagulability and secondary hyperfibrinolysis exist in patients with late cerebral infarction after acute brain injury. And these hematological markers have clinical significance.

关 键 词：脑外伤 脑梗塞 纤溶 D-二聚体 组织型纤溶酶原激活物 

分 类 号：R651.15[医药卫生—外科学]