异种(猪)脱细胞真皮基质一次性包扎治疗深Ⅱ度烧伤  

Treatment of deep partial thickness burns by a single dressing of porcine acellular dermal matrix

作　　者：冯祥生[1] 潘银根[2] 谭家驹[1] 吴秋合[3] 沈锐[1] 阮树斌[1] 陈晓东[1] 张凤刚[1] 林泽鹏[1] 杜永军[1] 

机构地区：[1]佛山市第一人民医院烧伤整形科,528000 [2]江苏省启东市人民医院烧伤科 [3]济南市中心医院烧伤科

出　　处：《中华外科杂志》2006年第7期467-470,共4页Chinese Journal of Surgery

基　　金：国家重点基础研究发展规划项目(G1999054205-2-17)

摘　　要：目的 探讨应用异种（猪）脱细胞真皮基质一次性包扎治疗深Ⅱ度烧伤创面的临床应用效果。方法 1997年1月—2004年1月，应用异种（猪）脱细胞真皮基质一次包扎治疗50％-95％总体表面积（TBSA）、深Ⅱ度烧伤的患者67例[异种（猪）脱细胞真皮基质治疗组]；同期保痂治疗的50％-95％TBSA、深Ⅱ度的患者10例（保痂治疗组），观察创面愈合时间和愈合质量及其并发症发生情况。治愈患者经过3个月-2年的随诊，观察瘢痕增生情况。结果 异种（猪）脱细胞真皮基质治疗组深Ⅱ度创面中途基本不需换药，创面愈合时间缩短，平均（12．2±2．6）d，而保痂治疗组愈合时间为（27．4±3．5）d，差异具有统计学意义（P〈0．05）；同时，异种（猪）脱细胞真皮基质治疗组瘢痕增生情况较保痂治疗组明显减轻或者无瘢痕增生。结论 一次性覆盖异种（猪）脱细胞真皮基质可有效地治疗深Ⅱ度烧伤创面，能加快创面愈合，减轻瘢痕增生，从而降低烧伤感染和炎症反应综合征的发生。Objective To explore the effect of one dressing of porcine acellular dermal matrix on deep partial thickness burns. Methods From January 1997 to January 2004, sixty-seven cases of deep partial thickness total burned surface area （TBSA） from 50% to 90% burn wound were treated by a single dressing of porcine acellular dermal matrix（ the porcine acellular dermal matrix group）. Ten cases of deep partial thickness burned patients with the same TBSA treated by exposure method served as the exposure method group. The healing time of the wound was observed. The patients were followed up for 3 months to 2 years, and the scar proliferation was observed. Results The deep partial-thickness wound would be healed without dressing change in the porcine acellular dermal matrix group, and the average healing time was （ 12. 2 ± 2. 6） days. The average healing time of the exposure method group was （ 27.4 ± 3.5 ） days. Follow up of the patients within 3 months to 2 years showed that scar proliferation in the porcine acellular dermal matrix group was much less than that in the exposure method group, even no scar proliferation was observed in some patients. Conclusion Without tangential excision, autografting and dressing change, a single dressing of porcine acellular dermal matrix on deep partial thickness burn wound could shorten the healing time and inhibit scar proliferation.

关 键 词：烧伤 生物敷料 伤口愈合 瘢痕 

分 类 号：R644[医药卫生—外科学]