基于遥测技术的大鼠24小时心率变异性分析  

Analysis of Rat 24h Heart Rate Variability Based on Telemetry Technology

作　　者：宁钢民[1] 俞方敏[1] 白岩[1] 李海燕[1] 郑筱祥[1] 

机构地区：[1]浙江大学生物医学工程与仪器学院教育部生物医学工程重点实验室,杭州310027

出　　处：《生物医学工程学杂志》2006年第2期235-238,共4页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(30270381);教育部留学回国人员科研启动基金资助项目

摘　　要：本研究应用遥测技术连续记录大鼠在无束缚条件下24 h心电信号,并通过心率变异性(H eart ratevariab ility,HRV)频谱分析的方法研究大鼠24 h自主神经活动。大鼠24 h HRV分析结果表明:自主神经活动具有明显昼夜节律,在睡眠期迷走神经活动较活跃,而在清醒期以交感神经活动为主;HRV频谱中低频和高频成分的比值(LF/HF)随着睡眠深度的变化而波动。24 h HRV分析可以获得自主神经系统活动的丰富信息,并有助于研究自主神经系统在生理和病理过程中的调控作用。In this study ECG signal of unstrained rat was recorded by telemetry device, and heart rate variability （HRV） was analyzed in order to evaluate 24h autonomic nervous activity. The results demonstrated an obvious circadian rhythm in the autonomic nervous activity： sympathetic activity being dominant during wake phase, and parasympathetic activity, dominant during sleep phase. The ratio of the low frequency to high frequency components in HRV power spectrum （LF/HF） fluctuates with the change in the sleep stages. It is concluded that 24h HRV analyses may reveal plentiful information about the behavior of autonomic nervous system and thus facilitate the investigation of its regulating role in physiological and pathological processes.

关 键 词：心率变异性 遥测技术 自主神经活动 

分 类 号：R319[医药卫生—基础医学]