姜黄素对大鼠肝缺血再灌注早期肝组织一氧化氮和内皮素-1水平的影响  

Effects of curcumin on contents of nitric oxide and endothelin-1 in rat liver tissues in the early stage of ischemia/reperfusion

作　　者：向进见[1] 沈世强[1] 熊成龙[1] 余莉[1] 荣愈平[1] 

机构地区：[1]武汉大学人民医院普外科,430060

出　　处：《腹部外科》2006年第2期114-116,共3页Journal of Abdominal Surgery

摘　　要：目的探讨姜黄素对大鼠肝脏缺血再灌注早期损伤(再灌注1 h)的微循环影响。方法将大鼠随机分为假手术组(A组)、对照组(B组)和实验组(C组)。通过检测再灌注早期1 h血清转氨酶的水平、肝组织中NO和ET-1水平来评价姜黄素对大鼠肝脏缺血再灌注早期损伤(再灌注1h)的微循环影响。结果姜黄素可降低大鼠肝脏缺血再灌注早期损伤血清转氨酶的水平,减少肝组织中NO水平和抑制肝组织中ET-1生成。且肝组织中NO生成与血清ALT存在正相关,肝组织ET-1水平与血清ALT存在正相关。结论姜黄素可通过减少肝组织中NO生成、降低肝组织中ET-1表达来改善肝缺血再灌注早期损伤中微循环的紊乱,从而减少对肝缺血再灌注肝实质细胞的损伤。Objective To explore the effects of curcumin on the microcirculation of rat liver tissue in the early injury of ischemia/reperfusion（reperfusion for lh） injury. Methods Wistar rats were randomized into the following groups., groupA （sham operation）, groupB （DMSO lml for two times, control） and groupC（40 mg/kg curcumin for two times）. Level of transaminase in serum and contents of nitricoxide（NO） and endothelin-1 （ET-1） in liver tissues were determined to evaluate the effect of curcumin on the liver tissue microcirculation in the early lh）. Results Curcumin could decline the level of serum injury of ischemia/reperfusion（reperfusion for transaminase＂ and ET-1 in liver tissue, and declined the level of NO in liver tissue in the early injury of ischemia/reperfusion. At the same time, the level of NO in liver tissue was positively correlated to the level of serum alanine aminotransferase （ALT） ,while the ET-1 level in liver tissue was positively correlated with the level of serum ALT. Conclusion Curcumin can relieve the injury of hepatic cells by increasing the level of NO and decreasing the level of ET-1 in liver tissue to correct the disorder of liver microcirculation in the early injury of ischemia/reperfusion.

关 键 词：姜黄素 一氧化氮 大鼠 再灌注损伤 微循环 

分 类 号：R657.3[医药卫生—外科学] R714.431[医药卫生—临床医学]