急性心肌梗死患者IL-8、IL-10和TNF-α的水平变化及意义  

Changes and clinical significance of IL-8, IL-10 and TNF-α levels in acute myocardial infarction patients

作　　者：胡波[1] 叶少雄[1] 陈忠诚[1] 罗敏琪[1] 李朝霞[1] 

机构地区：[1]中山大学第三附属医院检验科,广东广州510630

出　　处：《中国现代医学杂志》2006年第7期1052-1054,1057,共4页China Journal of Modern Medicine

摘　　要：目的研究急性心肌梗死(AMI)患者血清白细胞介素-(8IL-8),白细胞介素-1(0IL-10)及肿瘤坏死因子-α(TNF-α)的水平变化及其意义。方法采用ELISH方法测定35例急性心肌梗死患者(A-MI),25例不稳定心绞痛患者(UA)及40例健康对照组(NC)血清IL-8、IL-10及TNF-α水平,同时对A-MI和UA患者进行药物治疗,分别测定治疗1周和6周后患者血清中的IL-8、IL-10及TNF-α水平变化。结果AMI及UA组IL-8、IL-10及TNF-α水平明显高于NC组(P<0.01)。AMI及UA患者经药物治疗后,血清中IL-8、IL-10及TNF-α的水平均明显低于药物治疗前(P<0.01)。结论IL-8、IL-10及TNF-α水平变化与AMI发病密切相关,在AMI的发生及发展过程中起重要作用。[Objective] To investigate the significance of the change of intcrleukin-8,interleukin-10 pnd tumor necrosis factor-α levels in acute myocardial infarction （AMI） patients. [Methods] Levels of serum interleukin-8, interleukin-10 and tumor necrosis factor-ct were assayed by ELISA in 40 normal subjects, 35 AMI patients and 25 unstable angina （UA） patients. Serum interleukin-8, interleukin-10 and tumor necrosis factor-α levels in the 35 AMI and 25 UA patients were examined after 1 week and 6 weeks of treatment. [Results] The level of serum interleukin-8, interleukin-10 and tumor necrosis factor-α in AMI and UA patients were significantly higher than those in healthy people, respectively （P 〈0.01）, The levels of serum interleukin-8, interleukin-10 and tumor necrosis faetor-α were significantly decreased after 6 weeks （P 〈0.01） of treatment in AMI and UA group. [Conclusion] The change of interleukin-8, interleukin-10 and tumor necrosis faetor-α were related to AMI, and play an important role in the development of AMI diseases.

关 键 词：急性心肌梗死 IL-8 IL-10 TNF-Α 

分 类 号：R542.22[医药卫生—心血管疾病]