药物干预孕27～29周胎膜早破性早产结局的分析  

Analysis of drug-intervention in patients with preterm premature rupture of membranes between 27 and 29 weeks of gestation

作　　者：王立俊[1] 左常婷[1] 王国华[1] 亓洪荣[2] 

机构地区：[1]山东大学山东省立医院妇产科,山东济南250021 [2]山东省泰安市中心医院妇产科,山东泰安271000

出　　处：《中国现代医学杂志》2006年第7期1063-1065,1068,共4页China Journal of Modern Medicine

摘　　要：目的评价早产前给予干预性地塞米松和抗生素治疗对孕27～29周胎膜早破性早产(pretermprematureruptureofmembranes,PPROM)结局的影响。方法采用回顾性研究的方法,对孕27～29周内发生PPROM孕妇产前使用地塞米松和抗生素后胎龄的延长、母体一般情况及新生儿结局的影响进行统计学分析。结果发现早产儿结局差异无显著性(P>0.05),包括RDS,IVH,肺炎发生率及死亡率。结论地塞米松和抗生素干预治疗对改善孕27～29周PPROM妇女的妊娠结局并无显著效果,但发现非感染状态胎儿延长胎龄结局良好。[Objective] To assess the effectiveness of intervention with antenatal maternal Dexaraethasone and antibiotics therapy in preterm premature rupture of membrane between 27 and 29 weeks of gestation. [Method] This retrospective study evaluated the effects of prolongation of pregnancy and intervention with maternal Dexamethasone and antibiotics therapy on perinatal and neonatal outcomes. [Result] There was no significant difference found （P 〉0.05） in neonatal outcomes, ,suchas respiratory distress syndrome, intraventricular hemorrhage, incidence of pneumonia and death. [Conclusion] There is not any beneficial effects of Dexamethasone in improving pregnancy outcomes with PPROM between 27 and 29 weeks, but prolongation of latency period without infection is good to the outcome.

关 键 词：胎膜早破性早产 地塞米松 

分 类 号：R714.21[医药卫生—妇产科学]