芝麻素对肾性高血压大鼠主动脉收缩功能、NO和ET含量的影响  

Effects of Sesamin on Contraction of Aortic Ring,NO and ET in Renal Hypertension Rats

作　　者：孔祥[1] 杨解人[1] 

机构地区：[1]皖南医学院,安徽芜湖241001

出　　处：《中国实验方剂学杂志》2006年第4期47-49,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：安徽省教育厅科研基金项目(2005KJ296)

摘　　要：目的:探讨芝麻素对肾性高血压大鼠的主动脉收缩功能、NO和ET含量的影响。方法:肾性高血压大鼠灌服不同剂量芝麻素(100、33、10mg.kg-1.d-1)6周,测定离体胸主动脉环对苯肾上腺素引起的收缩反应、NO和ET含量。结果:100mg.kg-1芝麻素组主动脉最大收缩张力明显降低,NO含量明显增加,ET含量明显减少(P<0.05)。结论:芝麻素能抑制主动脉收缩,改善血管内皮细胞功能。EAbstract~ Objective： To evaluate the effects of sesamin on contraction of aortic ring, NO and ET in rats with renal hypertension. Methods： Sesamin （ 100,33,10mg· kg^-1·d^-1 ） was orally given in renal hypertensive rats. The responses to phenylephrine on isolated aortic rings was recorded and the levels of NO and ET were measured in aorta after six weeks of treatment. Results： 100mg· kg^-1 sesamin could reduce maximum contraction, increase the content of NO and decrease the level of ET（ P 〈 0. 05）. Conclusion： Sesamin can inhibit aortic contraction and improve vascular endothelial cell impairment.

关 键 词：芝麻素 肾性高血压 主动脉环 一氧化氮 内皮素 

分 类 号：R285.5[医药卫生—中药学]