2型糖尿病伴发抑郁症患者生命质量研究  

A preliminary study of quality of life in patients with type 2 diabetes mellitus coexisting major depression

作　　者：姚军[1] 吴文源[1] 李春波[1] 顾明君[2] 韩玉麒 张秀珍[4] 张稀翎 

机构地区：[1]同济大学附属同济医院心身科,上海200065 [2]上海长征医院内分泌科 [3]上海第十人民医院内分泌科 [4]同济大学附属同济医院内分泌科,上海200065 [5]上海第六人民医院

出　　处：《中国行为医学科学》2006年第4期323-325,共3页Chinese Journal of Behavioral Medical Science

基　　金：铁道部课题(TDB001)

摘　　要：目的探讨2型糖尿病伴发抑郁症患者生命质量及其与抑郁焦虑症状的相关性。方法对48例2型糖尿病伴发抑郁症患者(试验组)进行抗抑郁治疗12周,采用健康状况调查问卷(SF36),汉密顿抑郁量表(HAMD17)、汉密顿焦虑量表(HAMA)在治疗前和治疗后分别进行评定;对社区中46例2型糖尿病不伴发抑郁症患者(社区组)采用SF36进行评定。结果(1)试验组患者治疗前生命质量因子分与多项HAMD、HAMA总分及各因子分呈显著负相关(HAMD:r=-0.42,-0.18,-0.37,-0.48,-0.42,-0.23,-0.18,-0.33;HAMA:r=-0.40,-0.19,-0.37,-0.30,-0.29,-0.13,-0.13,-0.08,P<0.01)。(2)试验组患者治疗后生命质量因子分的提高与HAMD、HAMA总分减分及各因子分的下降呈显著正相关。(3)试验组患者治疗前生命质量各因子分与社区组患者生命质量各因子分比较亦差异有显著性(P<0.01)。结论2型糖尿病伴发抑郁症患者的生命质量与其抑郁情绪密切相关,随着抑郁情绪的改善,患者生命质量也有明显提高。合并抑郁症的2型糖尿病患者生命质量较普通2型糖尿病患者低。Objective To explore the type 2 diabetes mellitus coexisting major depression patients＇ quality of life and relationship to patients＇ depression and anxiety symptom. Methods Assessed 48 type 2 diabetes mellitus coexisting nlajor depression patients with the Short-Form-36 （SF-36）, Hamilton Depression Scale （ HAMD17 ） and Hamilton Anxienty Scale（HAMA） before treatment and the end of the twelveth therapeutic week. Results （ 1 ） The total and factor score of quality of life is negatively correlated with HAMD and HAMA. （2） The improvement of the score of quality of life after treatment is significant correlated with the decrease of total score of HAMD and HAMA and some factor score. （3） The total and factor score of quality of life in this group patients with diabetes mellitus coexisting major depression is significant with simple diabetes mellitus patients in community group. Conclusion The type 2 diabetes mellitus coexisting major depression patients＇ quality of llfe is closely correlated to their depression and anxiety symptom. To improve patients＇ emotion can enhance the quality of life of them. The quality of llfe in coexisting depression disorder in the type 2 diabetes mellitus patient is lower than simple type 2 diabetes mellitus patient.

关 键 词：糖尿病 抑郁症 生命质量 

分 类 号：R587.2[医药卫生—内分泌]