急性冠状动脉综合征患者血清基质金属蛋白酶-2与C-反应蛋白水平  

Approach of clinical significance of serum C-respective protein and matrix metalloproteinases-2 levels in acute coronary syndrome patients

作　　者：丁巍[1] 魏渝娟[2] 万德中[3] 左云慧[3] 张浩[3] 禄秀秀[3] 

机构地区：[1]包头医学院在读研究生,内蒙古包头014010 [2]宁波大学附属第三医院急诊科 [3]包头医学院附属第三医院心内科

出　　处：《临床心血管病杂志》2006年第4期217-219,共3页Journal of Clinical Cardiology

摘　　要：目的:在血清学水平上探讨C反应蛋白(CRP)、基质金属蛋白酶2(MMP2)与冠状动脉粥样硬化斑块破裂的关系,评价CRP、MMP2水平作为粥样硬化斑块破裂的血清学指标的意义。方法:分别利用酶联免疫吸附法及散射比浊法对40例急性冠状动脉综合征(ACS)组、40例稳定型心绞痛(SAP)组、40例非冠心病者(正常对照组)外周血血清CRP、MMP2水平进行测定。结果:ACS组、SAP组血清CRP、MMP2水平明显高于正常对照组,差异具有统计学意义(P<0.01),ACS组血清CRP、MMP2水平明显高于SAP组,差异具有统计学意义(P<0.01);经相关性检验血清CRP和MMP2水平呈明显正相关(P<0.01)。结论:血清CRP、MMP2水平可反映斑块稳定性,可作为检测斑块破裂的血清学指标。Objective：To investigate the relationship between serum levels of C-respective protein （CRP）and matrix metalloproteinases-2 （MMP-2） and coronary atherosclerotic plaque rupture and its significance as serum target of plaque rupture. Method：The levels of CRP and MMP-2 in peripleral serum of 40 acute coronary syndrome （ACS） patients, stable angina pectoris（SAP） patients and 40 without coronary heart disease patients as control were measured, respectively by enzyme-llnked immunoassay（ELISA） and scatter rateturbidity. Result： The serum levels of CRP and MMP-2 in ACS group, SAP group were higher than that in without coronary heart disease group. The levels of CRP and MMP-2 in ACS group were higher than that in SAP group. There was a positive correlation between the levels of CRP and MMP-2. Conclusion： Elevation of serum level of CRP and MMP-2 are related with unstable plaque. It can be used as a serum target to judge plaque rupture.

关 键 词：急性冠状动脉综合征 基质金属蛋白酶-2 C-反应蛋白 

分 类 号：R541.4[医药卫生—心血管疾病]