微晶纤维素硫酸钠溶液的构象(英文)  

Conformation of Sodium Microcrystalline Cellulose Sulfate in Aqueous Solution

作　　者：李琳[1] 熊文雯[1] 王兆梅[1] 

机构地区：[1]华南理工大学轻化工研究所,广东广州510640

出　　处：《华南理工大学学报（自然科学版）》2006年第3期43-48,共6页Journal of South China University of Technology(Natural Science Edition)

基　　金：广东省自然科学基金资助项目(000453)~~

摘　　要：微晶纤维素硫酸钠是一种具有显著抗凝血活性的物质,其抗凝活性与其在溶液中的构象密切相关．为了解其抗凝活性,文中通过旋光度分析、粘度分析和刚果红螺旋一线团过渡分析,研究了微晶纤维素硫酸钠溶液的构象．旋光度分析表明,微晶纤维素硫酸钠在水溶液或弱碱溶液中具有规则的空间构象；由粘度分析也可得出同样的结果；刚果红螺旋-线团过渡分析表明,微晶纤维素硫酸钠在溶液中具有规则的空间构象,同时具有单螺旋结构与高级螺旋结构．Sodium microcrystalline cellulose sulfate （ NaCSMC） is a new type of effective anti-coagulant, whose anti-coagulant activity is closely related to the conformation in solution. In order to reveal the anti-coagulant activity of NaCSMC, the conformation of NaCSMC in aqueous solution was investigated by the optical rotation measurement, the viscosity analysis and the Congo red helix-coil transition analysis. The measurement results of op tical rotation show that the conformation of NaCSMC is regular in neutral or weak alkaline solution. The same results can also be obtained by means of viscosity analysis. Moreover, it is indicated by the Congo red helix-coil transition analysis that the conformation of NaCSMc in aqueous solution is of not only regular conformation but also single helix and multi-helix structures.

关 键 词：微晶纤维素硫酸钠 水溶液 粘度 构象 

分 类 号：O636.11[理学—高分子化学]