五味子提取液对犬心肌缺血再灌注损伤的保护作用  

Protective Effective of Schisandra Chinensis Extract on Ischemia-Reperfu- sion Injury in Dog Heart

作　　者：代友平[1] 唐国华[1] 习水平[1] 吕德裕[1] 

机构地区：[1]湖北咸宁医学院诊断学教研室,咸宁437100

出　　处：《中国生化药物杂志》1996年第2期50-53,共4页Chinese Journal of Biochemical Pharmaceutics

摘　　要：造成急性心肌缺血再灌损伤模型,测定静脉血中超氧化物歧化酶(SOD)活性、脂质过氧化物(LPO)含量、心肌梗塞面积和梗塞程度。评估五味子提取液对犬急性心肌缺血再灌注损伤的保护作用。结果发现,五味子提取液能提高SOD活性,明显降低静脉血中LPO含量,缩小心肌梗塞范围,减轻心肌梗塞程度。提示五味子提取液对犬心肌缺血再灌注时脂质过氧化损伤有良好的预防作用。A model of acute ischemia-reperfusion injury was used. SOD,LPO of venous blood,infarct size and infarct degree were determined to evaluate the protective effect of Schisandra Chinesis extract (SDE)on ischemia-reperfusion injury in dog heart. The results showed that SOD activity was enhanced, LPO content lowered,infarct size reduced and infarct degree lowered. The results also indicated that SCE have better protective effect on ischemia-reperfusion in dog heart.

关 键 词：五味子 心肌缺血 提取液 保护作用 药理 

分 类 号：R972[医药卫生—药品] R965.2[医药卫生—药学]