低剂量γ线对胚胎发育的影响  

EFFECTS OF LOW DOSE IRRADIATION ON DEVELOPMENT OF FETAL RATS IN UTERO

作　　者：符绍莲[1] 阮明[1] 文勇[1] 刘士辉[1] 饶用清[2] 胡梦娟[3] 

机构地区：[1]北京医科大学卫生毒理教研室 [2]北京医科大学放射医学教研室 [3]北京医科大学人体解剖教研室

出　　处：《北京医科大学学报》1990年第2期85-87,161,共3页Journal of Peking University(Health Sciences)

基　　金：国家自然科学基金

摘　　要：用致畸实验方法结合胎脑组织学光镜检查,首次发现怀孕13天Wistar大鼠受1.0 Gy照射,胎鼠(20天胎龄)端脑的部分颞叶皮质细胞分层紊乱,集成许多细胞团块,表现出与嗅、内脏有关的古皮质区对射线敏感。研究结果还表明:0.25 Gy组未见影响胚胎发育;0.5、1.0 Gy使胎鼠发育迟缓、脑重下降,呈剂量依赖关系。Pregnaant Wistar rats were exposed to a single whole body γ-rays at doses of 0.25, 0.50, 1.0Gyon day 13 of gestation, dose rate of 19.6 R/min. Pregnant rats were killed on the 20 th day afterconception. Fetuses were examined and measured. The results show that growth retardation in groups 0.5 and 1.0 Gy was observed by fetal weight,length, weight of the brain with spinal cord, skeleton development and microscopic examination ofthe brains. The changes were dose-dependent. 0.25 Gy could be a treshold dose. It merits attention that the developing brains of fetal rats are sensitive to ionizing radiation.Brain weight of fetal rats exposed to 0.5 Gy was reduced (P<0.05), brain weight reduced obviously(P<0.01) in 1.0 Gy group. Cells in telencephalon cortical layer were arranged disorderly. Someneural cells masses (roseate-formation) were found. These changes were mainly 1ocated in archicortexsuch as olfactory bulb, subiculum. The possible mechanism was discussed.

关 键 词：Γ线 辐射效应 胚胎发育 致畸 

分 类 号：Q691.5[生物学—生物物理学]