硫双灭多威农药的致突变性研究  

THESTUDIESONTHEMUTAGENESISOFTHIOCARB

作　　者：张必成[1] 苏志杰[1] 吕祁峰[1] 唐明德[1] 陈律[1] 高泽宣[1] 

机构地区：[1]湖南医科大学实验动物学部,湖南医科大学环境卫生教研室

出　　处：《癌变．畸变．突变》1996年第2期97-99,共3页Carcinogenesis,Teratogenesis & Mutagenesis

摘　　要：本文用微核试验、Ａｍｅｓ试验和精子畸形试验对硫双灭多威农药的致突变性进行检测，结果表明：（１）硫双灭多威农药剂量为２９．６ｍｇ／ｋｇ，５９．２ｍｇ／ｋｇ和８８．８ｍｇ／ｋｇ时，均不诱发昆明小鼠骨髓嗜多染红细胞的微核率增加；（２）对硫双灭多威农药为０．５．５．０，５０．５００和５０００μｇ／皿进行Ａｍｅｓ试验，结果表明该药未诱导ＴＡ９７、ＴＡ９８、ＴＡ１００和ＴＡ１０２的回变菌数增加；３）硫双灭多威农药剂量为７４ｍｇ／ｋｇ，１４８ｍｇ／ｋｇ和２９６ｍｇ／ｋｇ时，都不引起昆明小鼠精子畸形率的增加。因此，该药是一种非致突变性的化学物质。This paper reported the results of mutagenesis of thiocarb assayed withmicronu- cleus test of polychromatic erythroblast in mouse bone marrow;the salmonella mutagenicitytest(Ames test)and aberration of sperm test.the resuIts showed that thiocarb couldn’tin- crease the frcquency of micronuleus at the doses of 29.6mg/kg.59.2mg/kg and 88.8mg/kg;from 0.5-5000ug/plate,thiocarb didn'treduce the reversion frequencies in strain TA97,TA98,TA100 and TA102;thiocarb didn'talso increase the aberration rate of sperm at thedoses of 74mg/kg.148mg/kg and 296mg/kg,therefore,it is believed that thiocarb maybe safeon potential mutegenesis。

关 键 词：硫双灭多威 精子畸形试验 致突变性 农药 

分 类 号：R992[医药卫生—毒理学] X592.031[医药卫生—药学]