Electro-acupuncture on the iNOS of Lumbar lntervertebral Disk Tissues in Rats  

作　　者：张必萌 吴耀持 吴焕淦 沈健 朱忠春(译) 

机构地区：[1]No. 6 People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, P. R China [2]Shanghai Research Institute of Acupuncture and Moxibustion, Shanghai 200030, P. R China [3]Shuguang Hospital Affiliated to Shanghai University ofl-CM, Shanghai 200002, P. R China [4]不详

出　　处：《Journal of Acupuncture and Tuina Science》2006年第2期71-74,F0002,共5页针灸推拿医学（英文版）

摘　　要：Objective： The present study is to investigate the mechanism of dectrtyacupuncture in preventing and treating lumbar intervertebral disk displacement. Methods： Seventy-five Sprauge-Dawley rats were used to establish the models of lumbar intervertebral disk displacement by operation, and divided into five groups including electro-acupuncture group, western medicine group, acupuncture plus medicine group, model group and normal control group, then they were treated with corresponding therapeutic method. The expression of inducible nitric oxide synthase （iNOS） mRNA in the lumbar intervertebral disk tissues of rats was detected by RTPCR. Results： The expression of iNOS mRNA in the lumbar intervertebral disk tissues of rats in model group was compared with that in normal control group, the significant difference was found （P〈 0.01）; While the expressions of iNOS mRNA in the lumbar intervertebral disk tissues of rats in electroacupuncture group, western drug group and acupuncture plus medicine group were all inhibited, and compared with the model group, the significant differences were also found （P 〈 0.01）. Conclusion： Electro-acupuncture could inhibit the expression of iNOS mRNA in the lumbar intervertebral disk tissue.目的:探讨电针防治腰椎间盘移位的机理。方法:75只大鼠经手术造成椎间盘移位模型.成功后分为电针组.西药组.针药组.模型对照组和正常对照组.分别给予相应处理。RT-PCR 法测定椎间盘组织中 iNOS mRNA 的表达。结果:模型组大鼠椎间盘组织 iNOS mRNA 表达与正常组之间比较存在显著性差异(P<0.01);电针组、西药组、针药组对大鼠椎间盘组织 iNOS mRNA表达均受抑制.与模型组比较有显著性差异(P<0.01)。结论:电针具有抑制椎间盘组织内 iNOS的作用。

关 键 词：Intervertebral Disk Displacement ELECTROACUPUNCTURE INOS 

分 类 号：R246.9[医药卫生—针灸推拿学]