母血清锌、铜、钙水平 与神经管缺损  

MATERNAL ZINC COPPER AND CALCIUM LEVEL IN NEURAL TUBE DEFECTS

作　　者：安笑兰[1] 芦春林[1] 阮明[1] 王耐芬[2] 章京[2] 经永春[3] 

机构地区：[1]北京医科大学毒理教研室 [2]北京医科大学中心仪器室 [3]北京医科大学三院妇产科

出　　处：《北京医科大学学报》1990年第6期441-444,共4页Journal of Peking University(Health Sciences)

基　　金：国家自然科学基金

摘　　要：1987年1月至1988年12月,在北京(城、乡)测定了37例神经管缺损胎儿母血清锌、铜、钙水平,与68例正常孕产妇、25例其他畸形儿母血清各元素比较,未见显著差异,未看出神经管缺损与母血清锌缺乏有关,未看出钙对锌吸收的相互作用的影响。两组畸形儿母于孕早期接触各种化学毒物的例数显著多于正常对照组,统计学有高度显著性差异,但未见接触化学毒物对各元素含量的影响。Maternal serum zinc copper and calcium concentration were measured in 37 NTDs and 68 normalpregnancies. The mean serum zinc values in mothers of NTDs(8.5±1.9μmol/L) were similar to controlsubjects(8.4±1.9μmol/L). There was no significant difference (p>0.05). The results as observed su-ggested no association between low concentration of zinc in maternal serum and NTD. The mean serumcopper level and the value of Cu/Zn were similar in the two groups, without statistical differencebetween them. Serum calcium level in mothers of NTDs(2.53±0.33mmol/L) was similar to that ofnormal pregnancies (2.42±0.33mmol/L) and there was no significant difference (p>0.05). No corre-lation between the level of zinc and calcium was found in mothers of NTDs, nor in the normal cont-rol pregnancies. It was shown that there was no obvious interaction between the above elements innormal range of concentration.

关 键 词：神经管缺损 锌 铜 钙 胎儿 

分 类 号：R714.53[医药卫生—妇产科学]