不同治疗方法对ACST大鼠死亡率的影响  

Effect of Different Therapeutic Methods on the Mortality Rate In ACST Rats Model

作　　者：许锋[1] 吴威中[1] 胡立明[2] 徐东琴[2] 

机构地区：[1]天津中西医结合急腹症研究所,天津300100 [2]天津中医学院,天津300193

出　　处：《中国中医急症》1996年第2期86-88,共3页Journal of Emergency in Traditional Chinese Medicine

基　　金：国家中医药管理局资助项目

摘　　要：本文对比观察了单纯胆管减压内引流(减压)、减压+氨苄青霉素、减压+“活血清解灵”对急性重症胆管炎(ACST)大鼠死亡率的影响.为探讨不同治疗方法的作用机制,我们来用生物学测定方法对大鼠腹腔巨噬细胞分泌的TNFa、IL-1、IL-6水平进行了测定,并以^(35)S标记的大肠杆菌为示踪物观察不同疗法对肠道细菌移位的影响.结果显示,ACST大鼠死亡率高达76%,减压组和氨苄组的死亡率相近(37.3%,36.8%),中药组的死亡率最低(25%).不同治疗方法对死亡率的影响与其对肠道细菌移位和巨噬细胞活化的抑制作用呈平行关系.The rat models of acute cholangitis of severe type(ACST) and the internal drainage of the common bile duct were created in this study. We compared the therapeutic effects of three different managements on the mortality rate of ACST rats. We also studied the therapeutic mechanism using 35-S labelled E. coli to observe the bacterial translocation from the gut and bioassay to investigate the activity of TNF,IL-l,and IL-6 secreted by peritoneal macrophages. The managements include : Group 1,drainage of the common bile duct (CBD);Group 2, drainage of CBD+ampicillin ;Group 3, drainage of CBD+'Huo Xue Qing Jie Ling'(HXQJL). The results demonstrated that the mortality rate of ACST rats elevated significantly (76. 4%),and was reduced by 30% in group 1 and group 2. HXQJL expressed a favorable therapeutic efficacy,the mortality rate was lowest (25%) among the three groups. The influence of different therapeutic methods on the mortality rate par-relied with their inhibiton on the bacterial translocation and the hyperactivity of macrophages.

关 键 词：胆管炎 死亡率 细胞因子 细菌移位 治疗 

分 类 号：R259.757[医药卫生—中西医结合]