乙肝妊娠患者孕早期绒毛姐妹染色单体交换率的研究  

The study on Chorion Sister Chrimatid Exchange (SCE) Rate of the early pregnant women with hepatitis B

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作  者:岳淑芬[1] 宋芳[1] 赵紫薇[1] 郝奋[1] 

机构地区:[1]包头医学院组胚教研室,内蒙古包头014010

出  处:《中国优生与遗传杂志》2006年第4期64-64,20,共2页Chinese Journal of Birth Health & Heredity

摘  要:目的探讨乙肝患者体内遗传物质的损伤情况。方法选择正常对照组20例,单纯HbsAg(+)增高组16例,乙肝组16例,乙肝恢复组10例,HBsAg、抗HBe、抗HBc三阳组12例,脂肪肝组16例,做孕早期绒毛SCE率的检测。结果正常组、单纯HBsAg(+)增高组,乙肝组各组间自发和诱发SCE逐步增高,且各组间均有显著差异;乙肝恢复组SCE下降;其他肝病患者SCE均较低。结论乙肝妊娠妇女体内出现DNA损伤及修复功能障碍。Objective: To investigate the damage extent of germ plasm in the patients with hepatitis B. Methods: To detect the chorion SCE rate of the control group, including 20 normal pregnant women, Group 1, including 16 with increased HBsAg, Group 2 also including 16 with hepatitis B, Group 3, including10 with recovered hepatitis B, Group 4 including 12 with HBsAg ( + ), HBeAb ( + ), HbcAb ( + ) and Group 5 including 16 with fatty liver. Results: Spontaneous and induced SCE rate were increasing gradually in control group, Group 1 and Group 2. At the same time, there was significantly differences among the three groups. In Group 3 and the other two groups, SCE rate all decreased. Conclusron: DNA damnification and repair obstruction appeared in the pregnant women with hepatitis B.

关 键 词:乙肝 孕早期 绒毛 姐妹染色单体交换 

分 类 号:R714.2[医药卫生—妇产科学]

 

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