乙肝妊娠患者孕早期绒毛姐妹染色单体交换率的研究  

The study on Chorion Sister Chrimatid Exchange (SCE) Rate of the early pregnant women with hepatitis B

作　　者：岳淑芬[1] 宋芳[1] 赵紫薇[1] 郝奋[1] 

机构地区：[1]包头医学院组胚教研室,内蒙古包头014010

出　　处：《中国优生与遗传杂志》2006年第4期64-64,20,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨乙肝患者体内遗传物质的损伤情况。方法选择正常对照组20例,单纯HbsAg(+)增高组16例,乙肝组16例,乙肝恢复组10例,HBsAg、抗HBe、抗HBc三阳组12例,脂肪肝组16例,做孕早期绒毛SCE率的检测。结果正常组、单纯HBsAg(+)增高组,乙肝组各组间自发和诱发SCE逐步增高,且各组间均有显著差异;乙肝恢复组SCE下降;其他肝病患者SCE均较低。结论乙肝妊娠妇女体内出现DNA损伤及修复功能障碍。Objective： To investigate the damage extent of germ plasm in the patients with hepatitis B. Methods： To detect the chorion SCE rate of the control group, including 20 normal pregnant women, Group 1, including 16 with increased HBsAg, Group 2 also including 16 with hepatitis B, Group 3, including10 with recovered hepatitis B, Group 4 including 12 with HBsAg （ ＋ ）, HBeAb （ ＋ ）, HbcAb （ ＋ ） and Group 5 including 16 with fatty liver. Results： Spontaneous and induced SCE rate were increasing gradually in control group, Group 1 and Group 2. At the same time, there was significantly differences among the three groups. In Group 3 and the other two groups, SCE rate all decreased. Conclusron： DNA damnification and repair obstruction appeared in the pregnant women with hepatitis B.

关 键 词：乙肝 孕早期 绒毛 姐妹染色单体交换 

分 类 号：R714.2[医药卫生—妇产科学]