肝肾移植患者早期细菌感染病原学分析  

Etiological analysis of earlyonset bacterial infections in patients with liver or kidney transplantation

作　　者：梁承晖[1] 罗显荣[1] 郑凤娇[1] 曾国兵[1] 刘树仁[1] 余宙耀[1] 

机构地区：[1]广州解放军第458医院,广东广州510602

出　　处：《海南医学》2006年第5期160-161,50,共3页Hainan Medical Journal

摘　　要：目的总结肝肾移植术后早期细菌感染病原学特点,为防治感染提供依据。方法回顾性分析61例肝肾移植术后患者细菌感染的发生率、感染细菌种类和耐药性。结果肝肾移植患者中30例发生细菌感染(49.18%),早期细菌感染主要是革兰阴性杆菌(77.78%),肝移植常见感染细菌依次为大肠杆菌、葡萄球菌和肺炎克雷伯菌,肾移植常见细菌感染依次为肺炎克雷伯菌、葡萄球菌和大肠杆菌。敏感抗生素为亚胺硫霉素、丁胺卡那霉素、氧哌嗪/他唑巴坦、万古霉素和利福平。结论细菌感染是肝肾移植后的主要并发症,肝肾移植后感染的细菌大多是多重耐药,抗生素的经验使用可选用亚胺硫霉素、丁胺卡那霉素、氧哌嗪/他唑巴坦、万古霉素和利福平。Objective To Summarize the etiological characteristics of earlyonset bacterial infections after liver or kidney transplantation and provide evidenco for its treatment. Methods The incidence of postoperative bacterial infections as well as species and resistance of bacterial in 61 patients receiving liver or kidney transplantation were retrospectively analyzed. Results Postroperafive Bacterial infections developed in 30 patients with liver or kidney transplantation （49.18%）. The major pathogens of earlyonset bacterial infection were GNB （77.78%）. The most common pathogens in patients with liver transplantation were Escherichia coil, staphylececcus and Idebsiella pneumoniae, the major pathogens of bacterial infections in patients with kidney transplantation were Idebsiella pneumoniae, staphylococcus and Escherichia coil The sensitive antibiotics included IMP, AK, P/T,VA and PIF etc. Conclusions Bacterial infection is a major complication after liver and kidney transplantetion, Most of the bacterial responsible for postoperative infection in recipients of liver and kidney transplantation are multi-drug resistant, IMP,AK,P/T,VA and RIF are better antibiotics for treatment of postoperative bacteria infction.

关 键 词：肝移植 肾移植 细菌感染 耐药性 

分 类 号：R446.5[医药卫生—诊断学]