泰康宁胶囊对海洛因依赖患者脱毒疗效与安全性的临床观察  

Clinical observations on efficacy and safety of TAIKANGNING capsules for detoxification of heroin-dependent patients

作　　者：梁军成[1] 徐国柱[1] 沈黎阳[1] 杨建辉 肖早香 李军 邓艳萍[1] 

机构地区：[1]北京大学中国药物依赖性研究所,北京100083 [2]宜昌市强制戒毒所,湖北宜昌443001

出　　处：《药物不良反应杂志》2006年第2期117-120,共4页Adverse Drug Reactions Journal

摘　　要：目的:观察泰康宁胶囊对海洛因依赖患者的脱毒效果及用药安全性。方法:采用开放试验设计,对50例海洛因依赖患者进行了观察。泰康宁胶囊常规口服剂量为1.5～3.0g,3次/d,根据戒断症状控制及不良反应情况增减剂量,最多可至4.0g,3次/d,连续用药10d。脱毒药效评价指标采用戒断症状逐日总体评分、主要戒断症状逐日分别评分、Hamilton焦虑量表(HAMA)评定。用药期间监测不良反应。结果:每日戒断症状总分、主要戒断症状逐日评分以及HAMA评分与用药前比较,差异均具有统计学意义(P<0.001)。不良反应主要有恶心呕吐、腹泻、口干、复视。对呼吸、心率、血压无影响。结论:泰康宁胶囊用于海洛因依赖患者脱毒治疗安全有效。Objective： To observe the efficacy and safety of TAIKANGNING capsules for the treatment of heroin withdrawal symptoms. Methods： Fifty heroin-dependent patients were treated with TAIKANGNING capsules in an open trial. The usual oral dose of TAIKANGNING was 1.5-3.0g, three times daily. The dosage of the drug was administered according to the withdrawal symptoms. The maximum dose was 4.0g three times daily for 10 day. Daily changes of total scores in withdrawal symtoms, daily changes of scores in each main withdrawal symptoms and changes of scores in HAMA （Hamilton anxiety scale） were adopted as index of detoxification efficacy. Results： The daily changes of total scores in withdrawal symptoms, daily changes of scores in each main withdrawal symptoms and changes of scores in HAMA were greatly reduced after administration of TAIKANGNING capsules. The difference was significant statistically in comparison with those of before treatment （P〈0.001）. The adverse reactions of TAIKANGNING capsules including nausea, vomit, diarrhea, dry mouth, blur version were observed. The influence of the drug on breath, heart rate and blood pressure was not found. Conclusion： TAIKANGNING capsules is effective and safe in the detoxification of heroin-dependent patients.

关 键 词：泰康宁胶囊 海洛因依赖 脱毒 

分 类 号：R277.7[医药卫生—中医学]