病毒性乙型肝炎患者血清中补体C_3、转铁蛋白、α_1-抗胰蛋白酶的检测及意义  

Detection and clinical significance of C_3、Tf、α_1-AT in serum of patients with hepatitis B.

作　　者：王忠[1] 刘毅[1] 闵福援[1] 刘惠珍[1] 

机构地区：[1]首都医科大学附属北京佑安医院临检中心,北京100069

出　　处：《临床肝胆病杂志》2006年第2期99-100,共2页Journal of Clinical Hepatology

摘　　要：探讨乙肝患者血清中补体C3(C3)、转铁蛋白(Tf)、α1-抗胰蛋白酶(α1-AT)含量的变化与肝脏损伤之间的关系。将患者分为急肝组(AH)、慢肝组(CH)、肝硬化组(LC)和肝癌组(HCC)。用速率散射比浊法检测。其结果为:C3各肝病组的含量与对照组相比都下降(P<0.05);AH组、CH组和HCC组均高于LC组,差异有显著性(P<0.01),Tf:各肝病组的含量与对照组相比都下降,差异有显著性(P<0.01)。AH组和CH组分别高于LC组、HCC组,差异有显著性。(P<0.01)α1-AT:AH组和HCC组高于对照组(P<0.01);HCC组高于CH组(P<0.05),差异有显著性。检测乙型肝炎患者血清中的C3、Tf、α1-AT含量,对监测患者肝脏损伤的程度和肝炎的进程有一定的参考意义。To study the relation between the change of concentration of complement 3 （C3） ,transferrin （Tf） and α1 - antitrypsin （α1 -AT） in sera of patients with hepatitis B and the damage of liver, healthy adults are used as controls. Patients with hepatitis B are divided into four groups ： Actue hepatitis （ all）, chronic hepatitis （ CH）, liver cirrhosis （LC） and liver cancer（HCC）. Detect the concentration by ratenephelometer. Results C3 ： All groups of hepatitis B are lower than the control group. AH,CH and HCC are higher than LC（P 〈0. 01 ）, The differences are significant. Tf： All the groups of hepatitis B are lower than the control group, the differences are significant （P 〈0. 01 ）. AH and CH are higher than LC or HCC, The differences are significant. （P〈0. 01 ） α1- AT： AH and HCC are higher than control （P 〈0. 01 ） ;HCC is higher than CH. （ P 〈 0.05 ） ; The differences are significant. There is a significance to observe the degree of the damage of liver and the course of hepatitis detecting the concentration of C3 ,Tf and α1 - AT in sera of patients with hepatitis B.

关 键 词：乙型肝炎 补体C3 转铁蛋白 Α1-抗胰蛋白酶 

分 类 号：R512.62[医药卫生—内科学]