醇取丹参液对几种口腔致病菌的体外抑菌作用  

An in vitro experiment on the antimicrobial effects of ethanol extract from salvia miltiorrhiza bunge on several oral pathogenic microbes

作　　者：邓婧[1] 张岱尊[1] 杨文静[1] 

机构地区：[1]青岛大学医学院附属医院口腔内科,山东青岛266003

出　　处：《上海口腔医学》2006年第2期210-212,共3页Shanghai Journal of Stomatology

基　　金：青岛市科技局资助项目[2001(市)-038]

摘　　要：目的:研究95%醇取丹参溶液对几种口腔常见致病菌的体外抑菌作用。方法:采用杯碟法检测丹参提取液对牙龈卟啉菌、伴放线放线杆菌、变形链球菌、乳酸杆菌的抑菌活性及最小抑菌浓度,并检测pH值的改变对其抑菌作用的影响。采用SPSS10.0统计软件包进行t检验。结果:95%醇取丹参液对牙龈卟啉菌、伴放线放线杆菌、变形链球菌、乳酸杆菌均有抑菌作用,最小抑菌浓度分别为15.62、15.62、62.50和15.62mg/ml。pH值由3.5上升到7.0时,对伴放线放线杆菌、变形链球菌、乳酸杆菌的抑菌活性减弱(P<0.05),对牙龈卟啉菌的抑菌活性无影响(P>0.05)。结论:95%醇取丹参溶液对口腔常见致病菌有抑制作用。PURPOSE： To study the in vitro antimicrobial activity of ethanol extract of salvia mihiorrhiza bunge on several oral pathogenic microbes. METHODS： Antimicrobial activities of ethanol extract of salvia mihiorrhiza bunge for porphyromonas gingivalis ATCC 33277, A. actinomycetes comitans ATCC 24523, Streptococcus mutans, and Lactobacillus were determined using the cup-plate method.The minimum antibacterial concentrations of ethanol extract of salvia miltiorrhiza bunge were measured. SPSS10.0 software package was used for Student＇s t test. RESULTS： Ethanol extract of salvia miltiorrhiza bunge had antimicrobial activities on Porphyromonas gingivalis, A.actinomycetemcomitans,Streptococcus mutans, Lactobacillus, and the minimum inhibitory concentrations were 15.62 mg/ml,15.62 mg/ml,62.50 mg/ml and 15.62mg/ ml; The pH of the solution was influential to its antimicrobial activity. CONCLUSION： Ethanol extract of salvia miltiorrhiza bunge has an antimicrobial activity on oral pathogenic microbes. Supported by Research Project of Science and Technology Bureau of Qingdao City （2001-038）.

关 键 词：丹参 口腔致病菌 抑菌实验 

分 类 号：R285.5[医药卫生—中药学]