骨康宁治疗实验性大鼠骨质疏松的影像与病理对照研究  

The effect of Gukangning capsule on the osteoporotic model of the rats induced by retinoic acid

作　　者：于伟利[1] 王世捷[1] 郭雄[2] 李润明[1] 赵丽华[3] 黄芳[3] 陈凯[1] 郭瑄[1] 

机构地区：[1]西安交通大学医学院第二附属医院放射科,陕西西安710004 [2]西安交通大学医学院地方病研究所,陕西西安710061 [3]西安交通大学医学院第二附属医院检验科,陕西西安710004

出　　处：《西安交通大学学报（医学版）》2006年第2期153-156,共4页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：陕西省科技攻关基金项目(No.2002K10-G8);西安交通大学医学院第二附属医院院基金项目(No.2001YJ-32)

摘　　要：目的探讨中药骨康宁治疗骨质疏松大鼠的效果。方法5-6月龄雌性SD大鼠,维甲酸复制骨质疏松模型后,给予中药骨康宁治疗。用影像学、骨病理组织学、形态计量学、骨生物力学等实验技术,观察骨康宁的治疗效果。结果经骨康宁治疗后,骨质疏松大鼠的平均骨小梁数、平均骨小梁宽、骨皮质指数、股骨骨密度、股骨的最大变形能力等增加,并明显高于骨质疏松组(P<0.05)。结论骨康宁对维甲酸诱导的大鼠骨质疏松有一定的治疗作用。Objective To understand the effect of Gukangning capsule on the osteoporotic model of the rats. Methods Female SD rats, 5--6 months after birth, were chosen to duplicate the osteoporotic model induced by retinoic acid and treated with Gukangning capsule. The effect of Gukangning capsule on osteoporosis was evaluated by radiology, morphometry, BMD and biomechanics of bone. Results After oral administration of Gukangning capsule, the mean trabecular plate density, the mean trabecular plate thickness and the trabecular bone volume, BMD and maximum strain of the rats, were significantly increased more than that of the osteoporotic model （P〈0.05）. Conclusion To some extent, Gukangning capsule has a therapeutic effect on the osteoporotic model of the rats induced by retinoic acid.

关 键 词：骨质疏松 骨康宁 维甲酸 影像 

分 类 号：R681[医药卫生—骨科学] R36[医药卫生—外科学]