马钱子碱在小鼠体内的组织分布  

Tissue distribution of brucine in mice

作　　者：李晓天[1] 张丽容[2] 王天奎 王红娟[1] 贾欣[1] 

机构地区：[1]郑州大学药学院 [2]郑州大学基础医学院 [3]河南电力医院

出　　处：《中国临床药理学与治疗学》2006年第3期342-344,共3页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的:研究马钱子碱在小鼠体内的组织分布。方法:小鼠灌胃60 mg.kg-1及静注10 mg.kg-1马钱子碱后用荧光分光光度法测定不同时间的组织浓度。结果:2种途径给药后马钱子碱在小鼠主要脏器分布相似,组织中以肝脏及肾脏浓度最高,然后依次是脾、心、肺、脑和胃,脂肪和骨骼肌含量最低。结论:马钱子碱在小鼠体内分布较广,且可穿透血脑屏障,进入中枢神经系统发挥作用。AIM： To study the tissue distribution of brucine in mice. METHODS： After ig and iv administraction of brucine at doses of 60 and 10 mg.kg^-1 in mice, the plasma and tissue concentrations at different time points were determined by fluorescence spectrophotometry. RESULTS： After ig and iv administraction, The main tissue distribution of brucine in mice was similar, the brucine concentrations in the liver and kidneywere the highest and those in the spleen, heart, lung, brain, stomach, fat and muscle decreased sequentially. CONCLUSION： There is an extensive distribution of brucine in mice and it has ability to permeate blood brain barrier.

关 键 词：马钱子碱 组织分布 荧光分光光度法 

分 类 号：R965[医药卫生—药理学]