肾康丸对早期糖尿病肾病大鼠肾小球系膜细胞分泌NO、TGF-β_1的影响  

Effect of Shenkangwan on mesangial cell NO and TGF-β_1 excretion in rats with early diabetic nephropathy

作　　者：陈国宝[1] 魏连波[1] 肖炜[1] 龙海波[1] 

机构地区：[1]南方医科大学珠江医院中西医结合肾病中心,广东广州510282

出　　处：《南方医科大学学报》2006年第4期526-528,共3页Journal of Southern Medical University

摘　　要：目的探讨肾康丸治疗早期糖尿病肾病的作用机制。方法采用血清药理学方法,观察肾康丸药物血清对早期糖尿病肾病大鼠肾系膜细胞分泌NO、转化生长因子-β1的影响。结果肾康丸药物血清能促进早期糖尿病肾病大鼠系膜细胞分泌NO、抑制转化生长因子-β1的分泌(P<0．05或P<0．01),上述作用随用药时间及药物浓度的升高而增强。结论肾康丸治疗早期糖尿病肾病的机制,与其促进系膜细胞分泌NO、抑制转化生长因子-β1的分泌,调节细胞因子网络平衡,达到防止细胞因子引起的系膜细胞损伤有关。Objective To study the mechanism of Shenkangwan （SKW） in treating early diabetic nephropathy （DN）. Methods The effect of SKW on NO and transforming growth factor （TGF）-β1 production by the mesangial cells （MCs） of rats with early diabetic nephropathy was evaluated with serum pharmacological method. Results Compared with normal serum, the SKW-containing serum dose- and time-dependently inhibited TGF-β1 excretion and increased NO production in the MCs of rats with early DN （P〈0.05 and P〈0.01, respectively）. Conclusion The therapeutic effect of SKW on early DN may rely on the balance modulation of cytokine network by increasing NO production and decreasing TGF-β1 excretion to prevent cytokine-induced damage of the MCs.

关 键 词：肾康丸 糖尿病肾病 NO 转化生长因子-Β1 

分 类 号：R285.5[医药卫生—中药学]