优降糖与美吡达在细胞水平上降血糖作用机理的探讨  

Effect of glyburide and glipizide on hypoglycemic mechanism at the cellular level

作　　者：黄丹珊[1] 施曼珠[1] 贾培红[1] 王淑凤 

机构地区：[1]北京医科大学第一医院内分泌科

出　　处：《中国糖尿病杂志》1996年第1期24-27,共4页Chinese Journal of Diabetes

摘　　要：应用新生大鼠胰腺单层培养β细胞灌流系统研究优降糖与美吡达对胰岛素刺激的效果。含有１６．７ｍｍｏｌ／Ｌ葡萄糖的培养基中维持培养的β细胞，分别在优降糖与美吡达刺激下，０天与７天全程培养期中均引起胰岛素分泌。结果：１６．７ｍｍｏｌ／Ｌ葡萄糖浓度时优降糖刺激效果更为显著，而美吡达刺激效果相对减弱且胰岛素高峰出现迟于优降糖。从而得知：尽管优降糖与美吡达同是磺脲类降糖药，但就其细胞水平上两者的作用机理可能有差异，从其总的刺激效果来看美吡达弱于优降糖。The effects of glyburide and glipizide on insulin secretion were studied in pancreatic monolayer cultured β cells of neonatal rats by a perfusion system in TCM199 medium containing 16.7mmol/L glucose,0.4～1mmol/L glyburide or glipizide were added to stimulate insulin release in rnonolayer cells for a total of 7 days,Glyburide induced stronger response of B cells.In contrast,the peak of insulin release induced by glipizide was lower and appeared later than that of glyburide.The stimulatory effects of either glyburide or glipizide were not significantly different between 0.4mmol/L and 1mmol/L concentrations.From the present data although glyburide and glipizide are sulfonylurea compounds of oral hypoglycemic agetits,their pharmacological mechanism of effect on B cells may be different.In general the stimulatory effect of glipizide is weaker then that of gluburide.

关 键 词：优降糖 美吡达 降血糖药 药理学 

分 类 号：R977.15[医药卫生—药品]