高同型半胱氨酸血症与血管阻塞性疾病相关性研究进展  

Research Advances on the Relationship Between Hyperhomocysteinemia and Obstructive Vascular Disease

作　　者：王芳[1] 席锐[1] 陆国平[1] 

机构地区：[1]上海交通大学医学院瑞金医院心内科,上海200025

出　　处：《上海交通大学学报（医学版）》2006年第4期427-429,共3页Journal of Shanghai Jiao tong University:Medical Science

摘　　要：高同型半胱氨酸血症是动脉和静脉阻塞性血管疾病的独立危险因素。引起高同型半胱氨酸血症的主要因素可分为遗传因素和非遗传因素,其致病机理还不明确,可能与内皮功能紊乱、脂质代谢异常、血管内膜中层增厚、血小板聚集增加、凝血因子受干扰等有关。该文就同型半胱氨酸的代谢及其致病机制作综述,为治疗高同型半胱氨酸血症提供理论基础。Hyperhomocysteinemia is an independent risk factor for arterial and venous obstructive vascular diseases. Raised plasma homocysteine concentrations are caused by genetic and non-genetic factors. The pathogenic mechanism is not clear. It may he associated with endothelium dysfunction, abnormal lipid metabolism, hypertrophy of intima media, increased platelet aggregation and several clotting factors interfered, etc. The metabolism and pathogenic mechanism of homocysteine are reviewed in this article, which provides theoretical foundation for the treatement of hyperhomocysteinemia.

关 键 词：同型半胱氨酸 高同型半胱氨酸血症 动脉粥样硬化 血栓形成 血管阻塞性疾病 

分 类 号：R589.2[医药卫生—内分泌]