CD54、CD80、HLA-DR在Graves病和桥本甲状腺炎甲状腺滤泡上皮中的表达  

Expressions of CD54, CD80 and HLA-DR in thyroid epithelial cells from the patients with Graves′ disease and Hashimoto′s thyroiditis

作　　者：刘东方[1] 邓华聪[2] 许改平[1] 雄波 侯平 

机构地区：[1]重庆医科大学附属第二医院内分泌科,400010 [2]重庆医科大学附属第一医院内分泌科 [3]壁山县人民医院外科 [4]壁山县人民医院内科

出　　处：《中华内分泌代谢杂志》2006年第2期110-113,共4页Chinese Journal of Endocrinology and Metabolism

基　　金：重庆卫生局2001-1-15青年人才基金项目

摘　　要：目的观察正常人、Graves病(GD)、桥本甲状腺炎(HT)、甲状腺组织CD54、CD80、HLA-DR的表达。方法免疫组化SP法测定上述各组甲状腺组织CD54、CD80、HLA-DR的表达水平。结果正常甲状腺组织甲状腺滤泡上皮细胞(TEC)几乎不表达CD54和HLA-DR,而GD组和HT组有较高水平的CD54和HLA-DR表达,以HT表达水平最高,3组间比较差异有统计学意义(均P<0.01);HT患者甲状腺CD80表达高于GD组和正常人,差异有统计学意义(均P<0.01),GD组甲状腺CD80表达很低,与正常人相比差异没有统计学意义。结论CD54和HLA-DR在GD和HT的发病机制中起重要作用,CD80在HT的发病中起重要作用。Objective To observe the expressions of CD54, CD80 and HLA-DR in thyroid epithelial cells （TEC） from normal subjects, patients with Graves＇ disease （GD） and Hashimoto＇s thyroiditis （HT） . Methods The expressions of CD54,CD80 and HLA-DR in TEC were assayed by immunohistochemical methods. Results As compared with normal thyroid tissues, the expressions of CD54 and HLA-DR in GD group and HT group were significantly increased （ all P 〈 0.01 ） ; expression of CD80 in HT group was higher than that in normal subjects and GD group （ both P 〈 0. 01 ） , but no different expression of CD80 was found between GD patients and normal subjects. Conclusion Elevated expressions of CD54 and HLA-DR in TEC seem to play an important role in the pathogenesis of GD and HT, while CD80 may contribute to the pathogenesis of HT.

关 键 词：格雷夫斯病 桥本甲状腺炎 甲状腺 胞间黏附分子1(CD54) 抗原 CD80 HLA-DR抗原 

分 类 号：R581[医药卫生—内分泌]