19例丙基硫氧嘧啶引起抗中性粒细胞胞浆抗体相关小血管炎的临床分析  

Clinical characteristics of nineteen vasculitis patients associated with propylthiouracil-induced antineutrophil cytoplasmic antibody

作　　者：高莹[1] 赵明辉[2] 叶华[1] 郭晓蕙[1] 

机构地区：[1]北京大学第一医院内分泌科,100034 [2]北京大学第一医院肾内科,100034

出　　处：《中华内分泌代谢杂志》2006年第2期124-126,共3页Chinese Journal of Endocrinology and Metabolism

基　　金："十五"国家科技攻关计划资助项目(2004BA720A30)

摘　　要：分析19例丙基硫氧嘧啶(PTU)引起抗中性粒细胞胞浆抗体相关小血管炎患者的临床资料,其中17例患Graves病,18例服用PTU超过2年。多表现为多系统受累,78.9%肾受累,42.1%肺受累,关节痛、皮疹及发热也很常见。所有患者均停用了PTU,内脏受累较重的患者应用了免疫抑制治疗。Clinical data were analysed in 19 patients with propylthiouraeil （PTU） -induced antineutrophil cytoplasmic antibody associated vasculitis. Among them, 17 patients （ 89.5% ） were diagnosed as Graves＇ disease originally. The duration of PTU therapy in 18 patients was more than two years. Multi-organ involvement was common, with 15 patients （78.9%） involved in kidneys and 8 patients （42. 1%） involved in lungs. The prevalenees of arthralgia, skin rash and fever were also high. All patients withdrew PTU, and some with severe organ involvements received prednisone and immunosuppressant.

关 键 词：丙硫氧嘧啶 抗体 抗中性白细胞胞质 血管炎 甲状腺功能亢进症 

分 类 号：R595.3[医药卫生—内科学]