Graves病患者碘营养状况与外周血细胞因子和单个核细胞抗原表达的关系  

Relationship between iodine intake and serum cytokines and antigen expressions of peripheral blood monocytes

作　　者：刘东方[1] 邓华聪[1] 许改平[2] 程伟[2] 曾晓华[2] 兰丽珍[1] 

机构地区：[1]重庆医科大学附一院内分泌科,现在400016 [2]重庆医科大学附二院

出　　处：《中华内分泌代谢杂志》2006年第2期128-129,共2页Chinese Journal of Endocrinology and Metabolism

基　　金：重庆卫生局青年人才基金资助项目(2001-1-15)

摘　　要：本研究探讨Graves病(GD)患者尿碘水平与外周血细胞因子和单个核细胞(PBMC)表面抗原的关系。结果表明高碘摄入可能加重GD突眼、甲状腺肿大等症状,IL-1β等细胞因子和PBMC表达的HLA-DR、CD80异常与高碘导致的免疫紊乱可能有一定关系。The relationship among iodine intake and serum eytokine level and expressions ot antigens on peripheral blood monocytes （PBMC） of GD patients was investigated. The results indicated that high iodine intake may aggravate clinical symptoms such as thyroeele and ophthalmopathy in GD patients. The abnormal increase of cytokine IL-1β and expressions of CD80 and HLA-DR on PBMC seem to be involved in immune disturbance.

关 键 词：格雷夫斯病 碘 外周血单个核细胞 细胞因子 

分 类 号：R581.1[医药卫生—内分泌]