碘对大鼠甲状腺钠碘转运体mRNA表达及甲状腺功能的影响  

Effects of iodine on the thyroid sodium iodide symporter mRNA expression and thyroid function in rats

作　　者：聂秀玲[1] 阎玉芹[1] 陈祖培[1] 

机构地区：[1]天津医科大学内分泌研究所,300070

出　　处：《中华内分泌代谢杂志》2006年第2期149-150,共2页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金重点课题资助项目(30230330)

摘　　要：观察不同碘摄入量对大鼠甲状腺钠碘转运体(NIS)mRNA、血清甲状腺激素、尿碘水平以及甲状腺组织碘含量的影响。低碘组NISmRNA表达明显增强,而血清甲状腺激素、尿碘、甲状腺组织碘含量显著下降。高碘组NISmRNA表达受到抑制,甲状腺激素有下降趋势。提示NIS是甲状腺自身调节的重要组成部分。高碘、低碘均可导致甲状腺功能低下。The effects of different iodide intakes on the thyroid sodium iodide symporter （NIS） mRNA expression, thyroid hormones, urinary iodine and tissue iodine in thyroid were observed. NIS mRNA expression was elevated; and urinary iodine, thyroid tissue iodine and thyroid hormones were significantly lowered in low iodine group. In high iodine group, NIS mRNA expression was inhibited and thyroid hormones decreased. The results show that NIS is the important component of this autoregulatory mechanism. Both low and high iodine intakes can lead to hypothyroidism.

关 键 词：碘 甲状腺功能减退症 钠碘转运体 大鼠 

分 类 号：R581[医药卫生—内分泌]