淫羊藿苷壳聚糖/明胶微球的制备及其体外释放研究  

Preparation and in vitro Release of Icariin-loaded Chitosan/Gelatin Microspheres

作　　者：张爱华[1] 姚康德[1] 

机构地区：[1]天津大学高分子材料研究所,天津300072

出　　处：《高分子通报》2006年第4期60-64,共5页Polymer Bulletin

基　　金：国家重大基础研究规划项目(G1999054305)

摘　　要：本试验以壳聚糖、明胶为载药基质,以中药淫羊藿苷为模拟药物,通过乳化交联的方法制备淫羊藿苷/壳聚糖/明胶微球。考察微球的理化特性,建立持续流动释放系统,检测了微球的体外释放特性和影响因素。微球的理化特性受工艺条件如搅拌速度、乳化剂用量、交联剂用量等因素影响。微球的体外释放速率与微球的粒径、交联度负相关,与载药量正相关。试验结果表明,壳聚糖、明胶可作为缓释微球的载体基质,微球制备工艺简单稳定,微球的释放速率可控,淫羊藿苷/壳聚糖/明胶微球是一种良好的药物释放体系。In this paper, icariin/chitosan/gelatin microspheres were achieved by emulsification and cross-linking methods. Physical and chemical characteristics of the microspheres were detected. A continual flowing system was used to determine releasing characteristics of microspheres and influencing factors. The study result indicated that the physical and chemical characteristics of microspheres were influenced by process conditions such as. rate of mixing round, quantity of emulsification and cross-linking agents, the in vitro release rate was negatively correlated with granule diameter and crossing-linking extent, positively correlated with drug contents. We can concluded that it was feasiable for chitosan and gelatin to act as carriers of slow release of microspheres, and the release rate of drug from microspheres was adjustable.

关 键 词：壳聚糖 明胶 微球 淫羊藿苷 体外释放 

分 类 号：TQ460.1[化学工程—制药化工]