坎地沙坦对心肌梗死后大鼠心肌组织TGF-β_1表达的影响  

Effect of Candesartan on Expression of Transforming Growth Factor-β_1 in Rats after Myocardial Infarction

作　　者：张常健[1] 

机构地区：[1]襄樊市中心医院老年病科,襄樊441000

出　　处：《华中科技大学学报（医学版）》2006年第2期170-172,共3页Acta Medicinae Universitatis Scientiae et Technologiae Huazhong

摘　　要：目的观察坎地沙坦对心肌梗死大鼠心肌组织非梗死区转化生长因子β1(TGF-β1)表达的影响。方法结扎左冠状动脉前降支建立大鼠心肌梗死模型,实验随机分为梗死治疗组[10 mg/(kg.d)坎地沙坦]、梗死对照组[15 ml/(kg.d)生理盐水]和假手术组[15 ml/(kg.d)生理盐水]。观察上述3组在心肌梗死后第8周的血流动力学和炎症细胞因子TGF-β1mRNA和蛋白的表达。结果与假手术组相比,梗死对照组心肌组织非梗死区TGF-β1明显增高,而梗死治疗组TGF-β1的表达随着心室重塑的改善而显著下降。结论TGF-β1参与了心肌梗死后的心室重塑,坎地沙坦通过减少TGF-β1的表达改善了心室重塑,坎地沙坦可作为防治心室重塑的策略之一。Objective To observe the effect of candesartan on the expression of transforming growth factor-β1 （TGF-β1） mRNA and protein in the noninfarcted myocardium. Methods Myocardial infarction model was established by left anterior de scending branch ligation. The rats were divided into three groups, candesartan treated group, myocardial infarction （MI） group and sham operation group. Candesartan treated group were administered with candesartan （ 10 mg/kg every day）, while MI group and sham operated group with saline 15 ml · kg^-1 · d^-1. The hymodynamic parameter and the expression of TGF-β1 mRNA and protein were measured after 8 weeks. Results The expression levels of TGF-β1 mRNA and protein were higher in MI group than in the sham-operated group （P〈0.01）. Compared with MI group, Candesartan treated group showed the sig- nificant attenuation of TGF-β1 in the infarcted myocardium, which was accompanied with the amelioration of myocardial remodeling process （P〈0.01）. Conclusion TGF-β1 participated in the myocardial remodeling. The effect of candesartan on reduction of the expression of TGF-β1 may be one of the strategies preventing and treating myocardial remodeling.

关 键 词：心肌梗死 心室重塑 坎地沙坦 

分 类 号：R542.22[医药卫生—心血管疾病]