纳米晶胶原基骨材料在临床上的应用  

Clinical Application of Nano-hydroxyapatete/collagen Composite

作　　者：沈铁城[1] 黄永辉[1] 徐晓峰[1] 崔福斋[2] 李艳[2] 任永娟[2] 

机构地区：[1]江苏大学附属医院骨科,212001 [2]清华大学材料科学与工程系,北京100084

出　　处：《医学研究杂志》2006年第4期70-73,共4页Journal of Medical Research

摘　　要：目的观察纳米晶胶原基骨材料(nano-hydroxyapatite/collagen,nHAC)种植人体后的骨修复效果,探讨该材料的临床应用前景。方法采用仿生方法制备纳米相羟基磷灰石/胶原复合材料,并用于临床,通过影像学方法观察和评价病人骨创愈合情况。结果纳米晶胶原基骨材料在成分与微结构上与天然骨类似,种植人体后患者无高热、渗出和免疫排斥反应,骨修复情况良好。结论纳米晶胶原基骨材料是优良的骨修复材料之一。Objective To observe the repairing effects of bone after nano - hydroxyapatite/collagen （ nHAC）being implanted in and to study its prospect in clinical application.Methods Nano- hydroxyapafite/collagen composite was developed by biomimetic method. The material was used in clinical operation, the healing effects of bone defects were assessed by methods of radiography. Results The composite showed some features of natural bone in both composition and microstmcture. After implanting, the patients were not hyperpyrexial, did not have extravasate and immunoreacfion, the bone defects were healing well. Conclusion The composite can serve as one of the promising materials for bone repairing.

关 键 词：胶原基复合材料 仿生合成 分级结构 骨缺损 骨移植 

分 类 号：R318.08[医药卫生—生物医学工程] R977.9[医药卫生—基础医学]