二步法磁共振预定位免疫成像对荷人结肠癌裸鼠增强作用的研究  

Studies on MR enhancement of SA-DTPA-Gd in nude mice bearing human colon carcinoma in MR pretargeting imaging

作　　者：叶靖[1] 许乙凯[1] 刘岘[2] 陆雪松[3] 许鹏君[1] 黄其鎏[1] 蒋志强[1] 吕国士[1] 

机构地区：[1]南方医科大学南方医院影像中心,广东广州510515 [2]广东省中医院放射科,广东广州510120 [3]南方医科大学南方医院神经内科,广东广州510515

出　　处：《医学研究生学报》2006年第4期323-326,共4页Journal of Medical Postgraduates

基　　金：国家自然科学基金资助项目(批准号:30371608);广东省自然科学基金资助项目(批准号:020053)

摘　　要：目的:探讨磁共振(MR)预定位免疫成像中SADTPAGd对靶瘤性的致增强作用。方法:两组荷人结肠癌细胞裸鼠分别经静脉注射SADTPAGd和GdDTPA,检测各组肿瘤组织和肝组织的信号强度。结果:SADTPAGd组在静脉给药后6h肿瘤强化率最高达70.2%,而GdDTPA组给药20min肿瘤的强化率最高为21.3%,两者间差异具有显著性意义。肝组织在SADTPAGd组峰值强化率为20.4%,而GdDTPA组最高为17.7%,两者之间差异不显著。结论:二步法MR预定位免疫成像技术对肿瘤具有显著的特异性增强作用,并有利于提高MR对病灶的敏感性。Objective ： To investigate the effect of SA-DTPA-Gd on MR enhancement in MR pretargeting immunology imaging. Methods：Mouses received tail vein （iv） or peritoneal cavity （ip） injection of SA-DTPA-Gd. The MR signal intensity of tumor and liver was determined. Results ： The maximum enhancement rate of tumor was 70.2% and 46.4%, in iv group and ip group respectively, and significant difference was found; there was no signifinant difference of the maximan enhancement rate of liver （23.7% in ip group and 20.4% in iv group）. Conclusion： Intravenous injection is in favor of SADTPA-Gd＇ s accumlation in tumor than intraperitoneal injection,, and is in favor of detection of tumor in MR imaging.

关 键 词：链霉亲和素 磁共振对比剂 预定位 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学]