胸腔内置管引流及药物治疗恶性胸腔积液的临床观察  

Clinical Research of Drainage with Microcatheter and Intrathoracic Cavity Drug Therapy for Malignant Pleural Effusion

作　　者：杨苏慧 孙建华 张彩清 

机构地区：[1]大同煤矿集团肿瘤医院

出　　处：《大同医学专科学校学报》2006年第2期5-6,共2页Journal of Datong Medical College

摘　　要：目的：观察胸腔内置管引流及药物治疗恶性胸腔积液的疗效及不良反应。方法：采用深静脉导管引流胸腔积液，对32例患者胸腔内注入顺铂（DDP）联合白细胞介素-2（IL-2），顺铂为60～80mg／次，白细胞介素-2为100万U／次。结果：32例患者中总有效率（CR＋PR）为81．3％（26／32）。部分患者出现发热、胸痛、恶心、呕吐等不良反应，经对症处理后可缓解。结论：胸腔内置管引流及胸腔内注入DDP联合IL-2治疗恶性胸腔积液的方法简便、安全，疗效较好，患者可耐受．值得临床推广。Objectives：To observe the effects and adverse reactions of drainage with microcatheter and intrathoracie cavity drug therapy for malignant pleural effusion. Methods： A new technique of microcatheter drainage was used in 32 patients with malignant pleural effusion, who accepted treatment of cisplatin（DDP60- 80 mg/time）plus Interlukin - 2（ IL - 21 × 10^7IU/time） injected intrathoracically. Results： Among 32 patients, overall response rates（CR ＋ PR）were 81.3 % （26/32）. The side effects of pyrexia, chest pain, nausea and vomiting were seen in some patients after drug was injected intrathoracically, and they could be relieved by symptomatic treatments. Conclusion. Drainage with microatheter is a convenient, safe method. Intrathoracic drug injection with cisplatin plus Interlukin- 2 can effectively control the malignant pleural effusion, and the patients were tolerant, So this method is worthy to be used widely for clinical.

关 键 词：微导管引流 恶性胸腔积液/药物疗法 顺铂 白细胞介素-2 

分 类 号：R561.3[医药卫生—呼吸系统]