抗痨药物对肺结核患者肝功能的影响  

Effect of antituberculesis drugs on liver functctions of the tuberculosis patient complicated with hepatitis is vivus infections

作　　者：聂彦芳 李霁虹[2] 

机构地区：[1]大同第四人民医院结核科 [2]大同市第四人民医院

出　　处：《大同医学专科学校学报》2006年第2期9-9,15,共2页Journal of Datong Medical College

摘　　要：目的:分析抗痨药物对HBV-M阳性患者肝功能的影响。方法:回顾性分析1370例肺结核病人中146例肝损害的相关临床资料。结果:94例HBV-M阳性患者中肝损害43例,其发生率为45.7%(43/94),1089例HBV-M阴性患者中肝损害57例,其发生率5.2%(57/1089),两组比较有显著差异(P<0.01)。HBV-M阳性患者肝损害发生的时间早,程度较严重。结论:在抗痨治疗前、中、后期应检查HBV-M及肝功能,尤其对HBV-M阳性者更应严密观察肝功能变化。Objective：To exeplore the influence to hepatic function causrd by liver virus infection of tuberculosis cases during chemical anti- tubercalesis treatment. Methods： Retrospctive analysis on the cllnicai clate of 1276 pulomary taterculosis cases（PTB）. There were evidences on liver function damaged of 186 cases. Results：43 cases（45.7 % ）out of 94 PTB suffered with HBV- M posistive were obsenred to be dameaged on their liver function. While 57（5.2 % ）out of 1089 suffered with HBV - M negutive. There was a significant difference（ P 〈 0.01 ）of liver function damaged ineidence between HBV- M positime and negatioe PTB cases. Conclusions：The liver virns infection during shortterm chemical treatment will influeace hepatic function. Testing HBV - M and hepatic function. Testing HBV M ang hepatic function is necessary before providing anti - tuberculosis tyearment for the PTB cases of hepatic function should be thben.

关 键 词：肺结核 乙型肝炎 肝功能 

分 类 号：R521[医药卫生—内科学] R978.3[医药卫生—临床医学]