蜂胶对辐射损伤大鼠外周血细胞及血清SOD的影响  

Effects of Propolis on White Blood Cells and Serum SOD in Rats Subjected to Pre-and Post-irradiation

作　　者：聂继华[1] 仲恒高[1] 杨小波[1] 苗超[1] 李建祥[1] 曹毅[1] 童建[1] 

机构地区：[1]苏州大学放射医学与公共卫生学院,苏州215123

出　　处：《环境与职业医学》2006年第2期149-150,共2页Journal of Environmental and Occupational Medicine

基　　金：江苏省重点实验室开放课题基金(编号:KJS01068)

摘　　要：[目的]观察黑蜂蜂胶对3．0Gy 60Co γ-射线照射大鼠外周血白细胞(WBC)及血清超氧化物歧化酶 (superoxide dismutase,SOD)活性的影响。[方法]将36只Wistar大鼠随机分成3组;单独照射组,蜂胶预防组,蜂胶治疗组。各组同时接受一次性全身γ射线照射。蜂胶预防组于照射前3 d起以0．2 g/kg灌服蜂胶,蜂胶治疗组于照射当天开始以同样剂量灌服蜂胶1次/d,连续7 d。各组于照前1 d,照后1、4、7 d采血。动态观察外周血白细胞数和SOD活性变化。 [结果]照射前、后给予蜂胶,在照后7d均显示出明显促进辐射大鼠白细胞数量的恢复。照射后4d,预防组和治疗组血清SOD活性与照射前相比差异无显著性。结果提示蜂胶可减轻辐射所致的大鼠血清SOD活性的下降。[结论]蜂胶具有一定的抗辐射损伤作用。[ Objective ] To observe the effect of Heifeng propolis on white blood cells（ WBC ） and serum SOD of rats pre-and post-irradiated with 3.0 Gy ^60Co γ -rays. [ Methods ] Changes in the SOD activity and WBC number in the pre- and postirradiated rats treated with propolis, were dynamically investigated. [ Results ] Treatment of propolis to rats pre- and postirradiated could facilitate recovery of the WBC and lessen the decrease in the SOD activity. [ Conclusion ] Propolis shows some effects of anti-irradiation under the experimental conditions.

关 键 词：黑蜂蜂胶 Γ射线 超氧化物岐化酶 白细胞 

分 类 号：R114[医药卫生—卫生毒理学]