Fn免疫组化染色在人病毒性心肌炎死后诊断中的应用  

Fibronectin immunohistochemical Staining for Diagnosing Sudden Death Caused by Viral Myocarditis

作　　者：李文胜[1] 巩庆进[2] 卢龙武[2] 张宜骏[2] 成建定[2] 

机构地区：[1]珠海市公安局拱北口岸分局,广东珠海519020 [2]中山大学基础医学院法医病理学教研室,广东广州510080

出　　处：《法医学杂志》2006年第2期84-85,F0004,共3页Journal of Forensic Medicine

基　　金：广东省医学科研基金项目(B2004027);广东省自然科学基金项目(05001685)

摘　　要：目的研究纤维连接蛋白(Fn)免疫组化染色对轻度病毒性心肌炎的病理学诊断价值。方法运用兔抗人Fn多克隆抗体对人类心肌炎心肌标本进行Fn-LSAB免疫组化研究。结果发现心肌炎心肌组织内Fn大量沉积,部分心肌细胞内Fn阳性。结论Fn-LSAB染色可显示轻度病毒性心肌炎的心肌损害,Fn沉积是心肌组织存在炎症性病理变化的可靠标志之一。Objective slight viral myocarditis To study the value of Fibronectin（Fn） immunohistochemical staining for diagnosing Methods The heart samples of human with myocarditis were studied by using LSAB immunohistochemical staining with anti-fibronectin antibody. Results Dense deposition was found in the myocardium of human with myocarditis. Some Fn-positive cardiomyocytes were observed. Conclusion Slight degeneration of cardiomyocytes could be identified by Fn-LSAB immunohistochemical staining and Fn-deposition is one of the reliable marks for inflammation in the myocardium.

关 键 词：病毒性心肌炎 纤维连接蛋白 免疫组织化学 

分 类 号：R827.17[医药卫生—临床医学] R259.422.1