牛传染性鼻气管炎病毒gB蛋白研究进展  

Advance in Infectious bovine rhinotracheitis virus Glycoprotein B

作　　者：李兆利[1] 薛飞[1] 朱远茂[1] 

机构地区：[1]中国农业科学院哈尔滨兽医研究所

出　　处：《动物医学进展》2006年第4期1-4,共4页Progress In Veterinary Medicine

摘　　要：牛传染性鼻气管炎病毒能引起牛多系统感染,是导致养牛业重大经济损失的一种重要病原。该病毒是有囊膜的双股DNA病毒,病毒囊膜蛋白在病毒致病中发挥了重要作用,其中gB蛋白对病毒的吸附、侵入、复制和细胞间扩散是必需的,可刺激机体产生大量的中和抗体。对gB蛋白的研究不仅是理解病毒分子生物学功能特征的需要,而且在临床诊断和疾病预防中也具有重要意义。文章就gB蛋白的结构特征、生物学功能以及在免疫学和诊断方面的研究做了综述,并对上述方面进行了展望。Infectious bovine rhinotracheitis virus（IBRV） is an important pathogen leading to significant economic damage, which causes multi-system infection in cattle. IBRV has double-stranded DNA with envelopes, the envelope glycoprotein B（gB）, which is one of immunodominant glycoproeins,is essential for attachment, penetration, direct cell-to-cell spread and replication of virus. Furthermore,it can stimulate the host to produce antibodies. Therefore,the research on gB is not only for understanding the function and characterization in the molecular biology of the virus but for the clinical diagnosis,prevention. So the relat- ed research on gB were reviewed. The expectation was made in every aspect above.

关 键 词：牛传染性鼻气管炎病毒 gB蛋白 生 物学功能 免疫学 诊断 

分 类 号：S852.659.1[农业科学—基础兽医学] S858.23[农业科学—兽医学]