氧化应激致胰岛β细胞损伤的研究进展  

Oxidative stress and islet beta cells

作　　者：赵琳[1] 邹大进[1] 

机构地区：[1]第二军医大学附属长海医院内分泌科,上海200433

出　　处：《国际内分泌代谢杂志》2006年第B04期11-13,共3页International Journal of Endocrinology and Metabolism

摘　　要：研究表明,氧化应激与糖尿病的发生、发展密切相关。高血糖导致活性氧簇(ROS)的过度表达,可使细胞内出现化学反应．从而导致DNA和蛋白质损伤修复以及脂质过氧化。了解ROS损伤机制是发展新的分子治疗和合理应用现有药物的第一步。有证据表明,他汀类药物、血管紧张素转换酶抑制剂类药物、血管紧张素Ⅱ受体1抑制剂及钙通道阻滞剂均有强大的细胞内抗氧化活性。Studies suggest that there is a close link between oxidative stress and beta cells damage. High blood glucose level determines overproduetion of reactive oxygen species （ROS） while high reactivity of ROS determines chemical changes in virtually all cellular components, leading to DNA and protein modification and lipid peroxidation. Learning of the mechanisms of ROS damage is the first step for developing new therapeutic molecules and for rationalizing the use of existing drugs. Evidence show that statins, angiotensin-converting enzyme inhibitors, angiotensin Ⅱ type 1 receptor antagonist, calcium channel blockers have a strong intracellular antioxidant activity.

关 键 词：氧化应激 活性氧簇 糖尿病 抗氧化剂 

分 类 号：R587.1[医药卫生—内分泌]