苦参汤中生物碱部位的化学成分  

Constituents in the alkaloid fraction of Kushen decoction

作　　者：刘斌[1] 石任兵[1] 

机构地区：[1]北京中医药大学中药学院,北京100102

出　　处：《中国中药杂志》2006年第7期557-560,共4页China Journal of Chinese Materia Medica

摘　　要：目的:研究苦参汤中生物碱部位的化学成分。方法:采用各种色谱法分离,运用多种波谱技术鉴定结构。结果:分离鉴定出8个化合物:苦参碱(matrine,Ⅰ)、槐定碱(sophoridine,Ⅱ)、槐果碱(sophocarpine,Ⅲ)、槐胺碱(sophoramine,Ⅳ)、氧化苦参碱(oxymatrine,Ⅴ)、氧化槐果碱(oxysophocarpine,Ⅵ)、苦豆碱(aloperine,Ⅶ)和鹰爪豆碱(sparteine,Ⅷ)。结论:这些化合物均为首次从苦参汤中分离得到,苦豆碱为首次在组成苦参汤复方的3味中药苦参、生地黄、黄芩中发现。Objective： To study the chemical comtituents of the alkaloid fraction of Kushen decoction. Method： Constituents were isolated by different kinds of column chromatography and their structures were elucidated with spectral methods. Result： Eight compounds were isolated and identified as matrine （ Ⅰ ）, sophoridine （ Ⅱ）, sophocarpine （ Ⅲ ）, sophoramine （Ⅳ）, oxymatrine （ Ⅴ ）, oxysophocarpine （ Ⅵ）, aloperine （ Ⅶ ） and sparteine （ Ⅷ ）. Conclusion： All these compounds were isolated from Kushen decoction for the first time. Aloperine was found firstly in Sophora flavescens, or Scutellaria baicalensis, or Rehmannia glutinosa which constituted Kushen decoction.

关 键 词：苦参汤 生物碱 

分 类 号：R284.1[医药卫生—中药学]