葛根黄酮对大鼠脑缺血再灌注损伤的保护作用  

Protective effect of pueraria flavonoid on the cerebral ischemic reperfusion injury in rats

作　　者：王培源[1] 王海萍[1] 李光武[1] 

机构地区：[1]安徽医科大学神经生物学研究所,安徽合肥230032

出　　处：《中国中药杂志》2006年第7期577-579,共3页China Journal of Chinese Materia Medica

摘　　要：目的:探讨葛根黄酮对脑缺血再灌注损伤的保护作用。方法:采用大鼠大脑中动脉栓塞模型,研究葛根黄酮对脑缺血再灌注脑组织含水量和脑梗死体积,脑组织中SOD,MDA的影响。结果:葛根黄酮能明显降低大脑中动脉大鼠脑含水量,缩小脑梗死体积,提高SOD的活性,减少缺血再灌大鼠MDA的含量。结论:葛根黄酮具有抗自由基损伤和保护缺血脑组织的作用。Objective： To research the protective effect of pueraria flavonoid on the cerebral ischemic reperfusion injury. Method： Using the middle cerebral artery occlusion model（MCA0）in rats, ＂we investigated the influence of pueraria flavonoid on the brain water content, the infarct volume, the activities of SOD, and the content of MDA. Result： Pueraria Flavonoid could obviously reduce the brain water content and the infract volume in MCAO,increase the activities of SOD, and decrease the content of MDA in the cerebral ischemia- reinfusion model of rats. Conclusion： Pueraria has the function of scavenging free radicals and the protective effect on ischemic brain tissue.

关 键 词：葛根黄酮 脑缺血再灌注 自由基 

分 类 号：R285.5[医药卫生—中药学]