脑安片对麻醉犬和大鼠脑血流动力学、软脑膜微循环的影响  

Effects of Naoan tablets on brain hemodynamics and cerebral microcirculation of soft membrane in anesthetized dogs and rats

作　　者：张大方[1] 王秀华[1] 李丽静[1] 蔡文静[1] 张亚杰[1] 

机构地区：[1]长春中医学院药学院,吉林长春130117

出　　处：《中国中药杂志》2006年第8期680-683,共4页China Journal of Chinese Materia Medica

摘　　要：目的:探讨中药复方脑安片对麻醉犬脑血流动力学和大鼠软脑膜微循环的影响。方法:血流动力学实验中以脑血流量、脑血管阻力、血压、心率等为观察指标;微循环实验以动脉管径和恢复血流的毛细血管数为观察指标。结果:脑安片0.5,1.0 g.kg-1均有显著增加麻醉犬脑血流量、降低血管阻力、降低血压的作用,而对心率影响不大。脑安片0.7,2.1 g.kg-1均有增加大鼠软脑膜恢复血流的毛细血管数和增大其动脉管径的作用。结论:脑安片可改善脑血流动力学指标,改善软脑膜微循环。Objective： To study the effects of Naoan tablets on brain hemodynamics and cerebral microcirculation of soft membrane. Mehtod： Cerebral blood stream flux, resistance of blood vessels, blood pressure and heart rate were used as observation indexes in hemodynamics experiment. Artery caliber and the number of capillaries with recovered blood stream were used as observation indexes in microcirculation experiment. Result： Naoan tablets at dose of 0.5 g·kg^-1 and 1.0 g·kg^-1 could enhance cerebral blood stream flux, decrease resistance of blood vessels, and reduce blood pressure. While no effects on heart rate. Naoan tablet at dose of 0.7 g·kg^-1 and 2.1 g·kg^-1 could increase the number of capillaries with recovered blood stream and enlarge the artery caliber of soft membrane in rats. Conclusion： Naoan tablets can improve the indexes of hemodynamics and cerebral microcirculation of soft membrane.

关 键 词：脑安片 脑血流动力学 脑血流量 血管阻力 血压 微循环 

分 类 号：R285.5[医药卫生—中药学]