荆花胃康胶丸对溃疡大鼠胃黏膜及6-keto-PGF_(1α)含量的影响  

Effects of pills for strengthening stomach in the management of gastric ulcers and gastric 6-keto-PGF_(1α) level of rats with ulcers

作　　者：张学智[1] 李超波[1] 刘正新[2] 梁文郁[1] 李江[3] 

机构地区：[1]北京大学第一医院中西医结合科,北京100034 [2]北京朝阳医院消化内科,北京100020 [3]北京大学第一医院消化内科,北京100034

出　　处：《中国新药杂志》2006年第7期522-524,共3页Chinese Journal of New Drugs

摘　　要：目的:研究荆花胃康胶丸对Okabe氏溃疡模型大鼠胃黏膜愈合及溃疡组织6-酮-前列腺素F1α(6-keto-PGF1α)含量的影响。方法:采用Okabe氏法,在大鼠胃前壁造成溃疡,随机将模型动物分为模型对照(生理氯化钠溶液)、荆花胃康胶丸大、中、小剂量(30,20,10 mg·kg-1·d-1)、硫糖铝10 mg·kg-1·d-1及法莫替丁5 mg·kg-1·d-1组,各组均灌胃给药,qd,连续10 d。给药结束后,计算各组大鼠溃疡面积和溃疡指数,测定溃疡组织黏膜缺损宽度及再生黏膜厚度,并定量检测胃组织的6-keto-PGF1α含量。结果:与模型对照组相比,荆花胃康胶丸组剂量依赖性地降低溃疡面积和溃疡指数及黏膜肌层缺损宽度,增加再生黏膜厚度和大鼠胃组织6-keto-PGF1α的含量(P< 0．01);荆花胃康胶丸30 mg·kg-1组的作用优于硫糖铝组及法莫替丁组(P<0．05)。结论:荆花胃康胶丸能促进溃疡愈合,其机制可能与增加溃疡组织6-keto-PGF的含量有关。Objective：To assess the effect of Jinghua pills for strengthening stomach （JPSS） in the management of gastric ulcers and level of 6-keto-PGF1α of rats. Methods：The gastric ulcer model of rats was established using the Okabe method. The rats with ulcers were randomly assigned to one of six groups ： model, three doses of JPSS （30,20,10 mg. kg^-1. d^-1 ） , sucralate （ 10 mg. kg^-1. d^-1 ） and famotidine （5 mg. kg^- 1. d^-1 ） group. The rats were intragrastrically administered with corresponding doses once a day for 10 days. The effectiveness was evaluated based on the status of the ulcer area and index, the width of the ulcer mucous and the thickness of regenerated mucous of the rats at the end of the therapy. The concentration of 6-keto-PGF1α, in gastric mucosal tissues was measured. Results：JPSS decreased dose-dependently the ulcer area and index, width of the ulcer mucous, and increased the thickness of regenerated gastric mucosa and 6-keto-PGF1α concentration compared with the model control（P 〈0.01 ）. The protective action of JPSS 30 mg.kg^-1 group was superior to that of sucralate and famotidine（ P 〈 0.05）. Conclusion ： JPSS may accelerate the healing of gastric ulcer by increasing the level of 6-keto-PGF1α of gastric mueosa in rats.

关 键 词：荆花胃康胶丸 胃溃疡 黏膜愈合程度 6-酮-前列腺素F1Α 

分 类 号：R975.6[医药卫生—药品] R961[医药卫生—药学]