神经递质调节剂普瑞巴林  

A neurotransmitter regulator: pregabalin

作　　者：何笑荣[1] 邹定[1] 吴学军[1] 李金娥[1] 

机构地区：[1]卫生部北京医院药剂科,北京100730

出　　处：《中国新药杂志》2006年第7期569-571,共3页Chinese Journal of New Drugs

摘　　要：普瑞巴林是神经递质γ-氨基丁酸(GABA)的一种类似物,能阻断电压依赖性钙通道,减少神经递质的释放。临床用于治疗外周神经痛、糖尿病性外周神经病(DPN)引起的疼痛、疱疹后神经痛(PHN)及部分癫痫发作的辅助治疗。对其药理作用、药动学及临床应用评价进行综述。Pregabalin is a gamma-aminobutyric acid （GABA） analogue with analgesic, anxiolytic and anticonvulsant activities. It reduces the release of neurotransmitters by interfering with the calcium channels at nerve terminals. Clinically, it has been used to treat peripheral neuropathic pain associated with diabetic peripheral neuropathy （DPN）, postherpetic neuralgia （PHN） and as an adjunctive treatment for epilepsy. This paper reviewed the mechanism, pharmacokinetics and clinical evaluation of pregabalin.

关 键 词：普瑞巴林 神经递质调节剂 外周神经痛 

分 类 号：R971.9[医药卫生—药品] R745[医药卫生—药学]